Mbosso Teinkela Jean Emmanuel, Siwe Noundou Xavier, Nguemfo Edwige Laure, Meyer Franck, Wintjens Rene, Isaacs Michelle, Mpondo Mpondo Albert Emmanuel, Hoppe Heinrich C, Krause Rui Werner Maçedo, Azebaze Anatole Guy Blaise
Département des Sciences Biologiques, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, BP 2701 Douala, Cameroon.
Department of Chemistry, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon.
Saudi J Biol Sci. 2018 Jan;25(1):117-122. doi: 10.1016/j.sjbs.2017.07.002. Epub 2017 Jul 20.
The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Roxb. ex Hornem. aerial roots (Moraceae) and Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. cell-growth inhibition activities were assessed on methanol extract of plant materials against strain 3D7 and , as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC value < 10 μg/mL. The extract of did not significantly reduce the viability of at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC of 2.4 μg/mL. In contrast, at the same concentration, the extract of exhibited plasmodiacidal activity (IC value of 9.5 μg/mL) and trypanocidal (IC value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.
对喀麦隆传统使用的两种药用植物的细胞毒性、抗疟和抗锥虫活性进行了评估。从喀麦隆的两个不同地点采集了桑科的白桂木气生根木材和卷柏科的卷柏叶。对植物材料的甲醇提取物针对3D7疟原虫株和布氏锥虫，以及针对人宫颈癌HeLa细胞的细胞生长抑制活性进行了评估。活性标准为IC值<10μg/mL。白桂木提取物在浓度为25μg/mL时未显著降低布氏锥虫的活力，但以2.4μg/mL的IC值显著影响锥虫生长。相比之下，在相同浓度下，卷柏提取物表现出抗疟活性（IC值为9.5μg/mL）和杀锥虫活性（IC值为0.9μg/mL）。两种提取物对HeLa癌细胞系均表现出低细胞毒性作用。这些结果表明，所选药用植物可进一步研究，以鉴定可能导致观察到的活性的化合物，这些化合物可能代表寄生虫药物发现的新线索。
