Okewole Adeniran Olubunmi, Adewuya Abiodun Olugbenga, Makanjuola Roger Olatokunbo Aderibigbe
Neuropsychiatric Hospital, Abeokuta, Nigeria.
Lagos State University College of Medicine, Lagos, Nigeria.
Schizophr Res Cogn. 2014 Oct 12;1(3):155-159. doi: 10.1016/j.scog.2014.08.003. eCollection 2014 Sep.
The study aimed to investigate correlates of cognition among patients with schizophrenia.
Over a three month period, in-patients diagnosed with schizophrenia (n = 50) and mood disorders (n = 50) were recruited into the study. Both groups of patients were assessed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN), the Annett Hand Preference Questionnaire (AHPQ) and the Global Assessment of Function Scale (GAF). Patients with schizophrenia were further assessed using the Positive and Negative Syndromes Scale, PANSS and the Clinical Global impression (CGI). The cognitive screen section of SCAN (comprising Verbal Trails Test and Mini Mental State examination, MMSE) and the cognitive factor of PANSS were used to assess cognitive function.
No differences were found in the cognitive profile of patients with schizophrenia and mood disorder. Among patients with schizophrenia, poor verbal performance was associated with the negative or mixed syndrome (p = 0.004), left or mixed handedness (p = 0.013), greater illness severity (p = 0.030) and lower GAF scores (p = 0.039). Poor performance on MMSE correlated with higher total PANSS score (p = 0.022) and was also associated with the negative or mixed syndrome (p = 0.003) and lack of clinical improvement (p = 0.035).
Patients with the negative or mixed schizophrenia syndrome may suffer more cognitive deficit. Poor verbal performance among patients with schizophrenia may be associated with left or mixed handedness, more severe illness and poor functioning.
本研究旨在调查精神分裂症患者认知功能的相关因素。
在三个月的时间里，招募了被诊断为精神分裂症的住院患者（n = 50）和情绪障碍患者（n = 50）参与研究。两组患者均使用神经精神病学临床评估量表（SCAN）、安妮特利手偏好问卷（AHPQ）和功能总体评定量表（GAF）进行评估。对精神分裂症患者进一步使用阳性和阴性症状量表（PANSS）和临床总体印象量表（CGI）进行评估。使用SCAN的认知筛查部分（包括言语追踪测试和简易精神状态检查表，MMSE）和PANSS的认知因子来评估认知功能。
精神分裂症患者和情绪障碍患者的认知概况未发现差异。在精神分裂症患者中，言语表现差与阴性或混合型综合征（p = 0.004）、左利手或混合利手（p = 0.013）、病情严重程度较高（p = 0.030）和GAF评分较低（p = 0.039）相关。MMSE表现差与PANSS总分较高相关（p = 0.022），也与阴性或混合型综合征（p = 0.003）和临床改善缺乏相关（p = 0.035）。
患有阴性或混合型精神分裂症综合征的患者可能存在更多认知缺陷。精神分裂症患者言语表现差可能与左利手或混合利手、病情更严重和功能较差有关。
