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印度的糖尿病和高血压:一项涉及 130 万成年人的全国代表性研究。

Diabetes and Hypertension in India: A Nationally Representative Study of 1.3 Million Adults.

机构信息

Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

出版信息

JAMA Intern Med. 2018 Mar 1;178(3):363-372. doi: 10.1001/jamainternmed.2017.8094.

Abstract

IMPORTANCE

Understanding how diabetes and hypertension prevalence varies within a country as large as India is essential for targeting of prevention, screening, and treatment services. However, to our knowledge there has been no prior nationally representative study of these conditions to guide the design of effective policies.

OBJECTIVE

To determine the prevalence of diabetes and hypertension in India, and its variation by state, rural vs urban location, and individual-level sociodemographic characteristics.

DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional, nationally representative, population-based study carried out between 2012 and 2014. A total of 1 320 555 adults 18 years or older with plasma glucose (PG) and blood pressure (BP) measurements were included in the analysis.

EXPOSURES

State, rural vs urban location, age, sex, household wealth quintile, education, and marital status.

MAIN OUTCOMES AND MEASURES

Diabetes (PG level ≥126 mg/dL if the participant had fasted or ≥200 mg/dL if the participant had not fasted) and hypertension (systolic BP≥140 mm Hg or diastolic BP≥90 mm Hg).

RESULTS

Of the 1 320 555 adults, 701 408 (53.1%) were women. The crude prevalence of diabetes and hypertension was 7.5% (95% CI, 7.3%-7.7%) and 25.3% (95% CI, 25.0%-25.6%), respectively. Notably, hypertension was common even among younger age groups (eg, 18-25 years: 12.1%; 95% CI, 11.8%-12.5%). Being in the richest household wealth quintile compared with being in the poorest quintile was associated with only a modestly higher probability of diabetes (rural: 2.81 percentage points; 95% CI, 2.53-3.08 and urban: 3.47 percentage points; 95% CI, 3.03-3.91) and hypertension (rural: 4.15 percentage points; 95% CI, 3.68-4.61 and urban: 3.01 percentage points; 95% CI, 2.38-3.65). The differences in the probability of both conditions by educational category were generally small (≤2 percentage points). Among states, the crude prevalence of diabetes and hypertension varied from 3.2% (95% CI, 2.7%-3.7%) to 19.9% (95% CI, 17.6%-22.3%), and 18.0% (95% CI, 16.6%-19.5%) to 41.6% (95% CI, 37.8%-45.5%), respectively.

CONCLUSIONS AND RELEVANCE

Diabetes and hypertension prevalence is high in middle and old age across all geographical areas and sociodemographic groups in India, and hypertension prevalence among young adults is higher than previously thought. Evidence on the variations in prevalence by state, age group, and rural vs urban location is critical to effectively target diabetes and hypertension prevention, screening, and treatment programs to those most in need.

摘要

重要性

了解印度这样一个大国的糖尿病和高血压患病率的差异对于针对预防、筛查和治疗服务的目标人群至关重要。然而,据我们所知,此前还没有针对这些情况的全国性代表性研究来指导有效政策的制定。

目的

确定印度的糖尿病和高血压患病率,并按邦、城乡位置以及个人层面的社会人口特征进行变化。

设计、地点和参与者:这是一项于 2012 年至 2014 年期间进行的全国性、代表性、基于人群的横断面研究。共有 1320555 名年龄在 18 岁或以上的成年人进行了血浆葡萄糖(PG)和血压(BP)测量,纳入了分析。

暴露因素

邦、城乡位置、年龄、性别、家庭财富五分位数、教育和婚姻状况。

主要结果和措施

糖尿病(PG 水平空腹时≥126mg/dL 或未空腹时≥200mg/dL)和高血压(收缩压≥140mmHg 或舒张压≥90mmHg)。

结果

在 1320555 名成年人中,有 701408 名(53.1%)为女性。糖尿病和高血压的粗患病率分别为 7.5%(95%置信区间,7.3%-7.7%)和 25.3%(95%置信区间,25.0%-25.6%)。值得注意的是,高血压在年轻年龄组中也很常见(例如,18-25 岁:12.1%;95%置信区间,11.8%-12.5%)。与最贫穷的五分位数家庭相比,处于最富裕的五分位数家庭中与糖尿病(农村:2.81 个百分点;95%置信区间,2.53-3.08 和城市:3.47 个百分点;95%置信区间,3.03-3.91)和高血压(农村:4.15 个百分点;95%置信区间,3.68-4.61 和城市:3.01 个百分点;95%置信区间,2.38-3.65)的概率只有适度的增加。按教育类别划分,这两种疾病的概率差异通常较小(≤2 个百分点)。在各邦中,糖尿病和高血压的粗患病率从 3.2%(95%置信区间,2.7%-3.7%)到 19.9%(95%置信区间,17.6%-22.3%)不等,高血压的粗患病率从 18.0%(95%置信区间,16.6%-19.5%)到 41.6%(95%置信区间,37.8%-45.5%)不等。

结论和相关性

在印度,所有地理区域和社会人口群体中,糖尿病和高血压的患病率在中年和老年时都很高,而年轻成年人的高血压患病率高于之前的估计。关于按邦、年龄组和城乡位置划分的患病率差异的证据对于有效地针对糖尿病和高血压的预防、筛查和治疗计划非常重要,以便将其针对最需要的人群。

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