恶性疟原虫中一段重复DNA序列的特征分析
Characterisation of a repetitive DNA sequence from the malaria parasite, Plasmodium falciparum.
作者信息
Oquendo P, Goman M, Mackay M, Langsley G, Walliker D, Scaife J
出版信息
Mol Biochem Parasitol. 1986 Jan;18(1):89-101. doi: 10.1016/0166-6851(86)90053-8.
PMID:2938003
Abstract
A repetitive DNA fragment cloned from the malaria parasite, Plasmodium falciparum, has been analysed. It contains a 21 base pair sequence which occurs in multiple tandem repeats. Two clusters of the same repeat are found in opposite orientations on the same DNA fragment. The repetitive DNA provides an additional way to distinguish between different strains of parasite by hybridisation to genomic blots and may serve as a species-specific probe for diagnosis.
摘要
对从疟原虫恶性疟原虫中克隆出的一个重复DNA片段进行了分析。它包含一个21个碱基对的序列，该序列以多个串联重复的形式出现。在同一DNA片段上以相反方向发现了两个相同重复序列的簇。这种重复DNA通过与基因组印迹杂交提供了一种区分不同寄生虫菌株的额外方法，并且可作为用于诊断的物种特异性探针。
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