Tishreen University, Latakia, Syria, Faculty of Dentistry, Department of Pediatric Dentistry.
Tishreen University, Latakia, Syria, Faculty of Pharmacy, Department of Medicinal Chemistry and Drugs Quality Control.
Eur J Paediatr Dent. 2017 Dec;18(4):285-290. doi: 10.23804/ejpd.2017.18.04.04.
To compare the clinical and radiographic success rates of an antibiotic mix consisting of metronidazole, minocycline and ciprofloxacin (3Mix-MP) and another mix where minocycline was replaced with clindamycin (3Mix-MP-R) in non-instrumentation endodontic treatment (NIET) of necrotic primary molars and to determine the effect of root resorption on the success of the treatment.
Forty-two necrotic mandibular primary molars from 22 healthy children were randomly assigned to either mixture. Blinded clinical evaluation was conducted after 1, 3, 6 and 12 months by the operator, and blinded radiographic evaluation was conducted at 6 and 12 months follow-ups by other two investigators with inter-examiner reproducibility of 0.95.
Overall success rates of 3Mix-MP and 3Mix-MP-R were 80.96% and 76.20% respectively, with no statistically significant difference. Radiographically, resorption of more than one third of the root length had a lower failure rate with no statistically significant difference (p<0.5).
Primary teeth with necrotic pulp can be treated with 3Mix-MP or 3Mix-MP-R irrespective of the degree of root resorption.
比较包含甲硝唑、米诺环素和环丙沙星（3Mix-MP）的抗生素混合物与用克林霉素替代米诺环素的另一种混合物（3Mix-MP-R）在非器械根管治疗（NIET）中的临床和放射成功率，以确定根吸收对治疗效果的影响。
将 42 颗来自 22 名健康儿童的下颌坏死乳磨牙随机分配到两种混合物中。在治疗后 1、3、6 和 12 个月由操作人员进行盲法临床评估，在 6 和 12 个月随访时由另外两名研究人员进行盲法放射评估，两名研究人员之间的检查重现性为 0.95。
3Mix-MP 和 3Mix-MP-R 的总体成功率分别为 80.96%和 76.20%，无统计学差异。在放射学上，根吸收超过三分之一的牙齿失败率较低，但无统计学差异（p<0.5）。
无论根吸收程度如何，坏死牙髓的乳磨牙均可使用 3Mix-MP 或 3Mix-MP-R 进行治疗。
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