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拉姆齐·亨特综合征合并颅神经炎的病例研究。

A case study of Ramsay Hunt Syndrome in conjunction with cranial polyneuritis.

作者信息

Zheng Ru-Wen, Liu Di, Eric Tay E, Ning Yan-Zhe, Chen Lu-Lu, Hu Hui, Ren Yi

机构信息

Department of Acupuncture and Moxibustion, Dongfang Hospital, The Second Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China Singapore Chung Hwa Medical Institution, Singapore Beijing Anding Hospital, Affiliated to Capital Medical University Department of Neurology, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.

出版信息

Medicine (Baltimore). 2017 Nov;96(47):e8833. doi: 10.1097/MD.0000000000008833.

DOI:10.1097/MD.0000000000008833
PMID:29381990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5708989/
Abstract

RATIONALE

Ramsay Hunt syndrome in conjunction with cranial polyneuritis is not extensively documented, and is very easily misdiagnosed.

PATIENT CONCERNS

A case of a 53-year-old male with Ramsay Hunt syndrome in conjunction with cranial polyneuritis is presented with early symptoms of vertigo, cephalalgia, and facial palsy, followed by zoster oticus 10 days later.

DIAGNOSES

Diagnosis was challenging as this condition presents with multiple neuropathies, and attempting to diagnose based on clinical symptoms was often misleading. Polymerase chain reaction can be used to test for presence of the virus in the cerebrospinal fluid, followed by targeted drug therapy.

INTERVENTIONS

Acupuncture, in conjunction with fire cupping, bloodletting around the afflicted region on the face, as well as oral consumption of herbal medicine and vitamins for nerve nourishment was given to treat this disease.

OUTCOMES

Due to misdiagnosis resulting in delayed treatment, peripheral facial paralysis was left as the main sequelae, while other symptoms responded quickly to treatment. After a 6-month follow-up, facial palsy was still present.

LESSONS

Considering that targeted antiviral therapy can be used to increase the effectiveness of treatment, early diagnosis, and timely use of medication is critical.

摘要

理论依据

拉姆齐·亨特综合征合并颅神经炎的病例记录并不广泛,且极易被误诊。

患者情况

本文介绍了一例53岁男性患有拉姆齐·亨特综合征合并颅神经炎的病例,其早期症状为眩晕、头痛和面瘫,10天后出现耳部带状疱疹。

诊断

由于该病症表现为多种神经病变,仅凭临床症状进行诊断往往具有误导性,因此诊断颇具挑战性。可通过聚合酶链反应检测脑脊液中是否存在病毒,随后进行针对性药物治疗。

干预措施

采用针灸结合拔火罐、在面部患病区域周围放血,以及口服草药和营养神经的维生素来治疗该疾病。

结果

由于误诊导致治疗延误,主要后遗症为周围性面瘫,而其他症状对治疗反应迅速。经过6个月的随访,面瘫仍然存在。

经验教训

鉴于可采用针对性抗病毒治疗提高疗效,早期诊断并及时用药至关重要。

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本文引用的文献

1
Facial diplegia resembling bilateral Ramsay Hunt Syndrome.类似双侧拉姆齐·亨特综合征的面瘫
J Neurol Sci. 2017 May 15;376:109-111. doi: 10.1016/j.jns.2017.03.011. Epub 2017 Mar 9.
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High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy.水痘带状疱疹病毒血管病变的高分辨率MRI血管壁成像
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Infection of the central nervous system caused by varicella zoster virus reactivation: a retrospective case series study.水痘-带状疱疹病毒再激活引起的中枢神经系统感染:一项回顾性病例系列研究。
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Herpes zoster oticus: a clinical model for a transynaptic, reflex pathways, viral transmission hypotheses.耳带状疱疹:一种用于病毒传递假说的突触前、反射通路的临床模型。
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Ramsay Hunt syndrome.拉姆齐·亨特综合征。
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Ramsay Hunt syndrome complicated by a brainstem lesion.拉姆齐·亨特综合征并发脑干病变。
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