Ansari Fereshteh, Sadeghi-Ghyassi Fatemeh, Yaaghoobian Barmak
a Iranian Evidence Based Center of Excellence, Tabriz University of Medical Sciences , Iran.
b Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
J Cosmet Laser Ther. 2018 Aug;20(4):248-251. doi: 10.1080/14764172.2017.1400173. Epub 2018 Jan 31.
Fractional CO has many indications in medicine including in treatment of acne scars and rejuvenation. The aim of this study was to evaluate the safety, efficacy, and cost-effectiveness of Fractional CO Laser in comparison with other methods of rejuvenation and acne scar treatment.
Several databases including Medline, OVID, EMBASE, CINHAL, SCOPUS, Web of science, CRD, and Cochrane were searched. After conducting the search and evaluation of selected publications, critical appraisal was done and eligible studies were accepted for inclusion in the systematic review.
From 2667 identified publications two of the trials were eligible. The effectiveness and complications of Fractional CO laser were comparable with Er:YAG but Fractional CO laser was 14.7% (p = 0.01) more effective than Q-Switched ND:YAG laser. Cost affectivity of this method was the same as other alternative lasers. In conclusion Fractional CO laser is an effective and safe method for curing of several kinds of skin diseases. Nevertheless there was not sufficient evidence to support its advantage. This device has equal or lower price in comparison to competent technologies except for the non- fractional ablative CO laser that has the same or lower price and comparable effects.
二氧化碳点阵激光在医学上有多种适应证，包括治疗痤疮瘢痕和皮肤年轻化。本研究的目的是评估二氧化碳点阵激光与其他皮肤年轻化和痤疮瘢痕治疗方法相比的安全性、有效性和成本效益。
检索了多个数据库，包括医学文献数据库（Medline）、OVID、荷兰医学文摘数据库（EMBASE）、护理学与健康领域数据库（CINHAL）、Scopus、科学引文索引（Web of science）、循证医学数据库（CRD）和考科蓝图书馆。在对选定的出版物进行检索和评估后，进行了批判性评价，并接受符合条件的研究纳入系统评价。
在2667篇已识别的出版物中，有两项试验符合条件。二氧化碳点阵激光的有效性和并发症与铒激光（Er:YAG）相当，但二氧化碳点阵激光比调Q开关钕:钇铝石榴石激光（Q-Switched ND:YAG）有效14.7%（p = 0.01）。该方法的成本效益与其他替代激光相同。总之，二氧化碳点阵激光是治疗多种皮肤病的一种有效且安全的方法。然而，没有足够的证据支持其优势。与同类技术相比，该设备价格相当或更低，但非剥脱性二氧化碳激光价格相同或更低且效果相当。
