Keya Jakia Jannat, Suzuki Ryuhei, Kabir Arif Md Rashedul, Inoue Daisuke, Asanuma Hiroyuki, Sada Kazuki, Hess Henry, Kuzuya Akinori, Kakugo Akira
Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Japan.
Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
Nat Commun. 2018 Jan 31;9(1):453. doi: 10.1038/s41467-017-02778-5.
In nature, swarming behavior has evolved repeatedly among motile organisms because it confers a variety of beneficial emergent properties. These include improved information gathering, protection from predators, and resource utilization. Some organisms, e.g., locusts, switch between solitary and swarm behavior in response to external stimuli. Aspects of swarming behavior have been demonstrated for motile supramolecular systems composed of biomolecular motors and cytoskeletal filaments, where cross-linkers induce large scale organization. The capabilities of such supramolecular systems may be further extended if the swarming behavior can be programmed and controlled. Here, we demonstrate that the swarming of DNA-functionalized microtubules (MTs) propelled by surface-adhered kinesin motors can be programmed and reversibly regulated by DNA signals. Emergent swarm behavior, such as translational and circular motion, can be selected by tuning the MT stiffness. Photoresponsive DNA containing azobenzene groups enables switching between solitary and swarm behavior in response to stimulation with visible or ultraviolet light.
在自然界中,群体行为在能动生物中反复进化,因为它赋予了各种有益的涌现特性。这些特性包括改进信息收集、抵御捕食者以及资源利用。一些生物,例如蝗虫,会根据外部刺激在独居和群体行为之间切换。由生物分子马达和细胞骨架细丝组成的能动超分子系统已展现出群体行为的某些方面,其中交联剂可诱导大规模组织形成。如果群体行为能够被编程和控制,此类超分子系统的能力可能会进一步扩展。在此,我们证明由表面附着的驱动蛋白马达推动的DNA功能化微管(MT)的群体行为可以通过DNA信号进行编程和可逆调节。通过调节MT的刚度,可以选择诸如平移和圆周运动等涌现的群体行为。含有偶氮苯基团的光响应性DNA能够响应可见光或紫外光刺激,在独居和群体行为之间实现切换。