Cheung Angel, Gong Mengqi, Bellanti Roberto, Ali-Hasan-Al-Saegh Sadeq, Li Guangping, Roig Eulàlia, Núñez Julio, Stamos Thomas D, Yilmaz Mehmet Birhan, Hakki Kaya, Wu William K K, Wong Sunny Hei, Wong Wing Tak, Bazoukis George, Lampropoulos Konstantinos, Tse Lah Ah, Zhao Jichao, Lip Gregory Y H, Baranchuk Adrian, Wong Martin C S, Liu Tong, Tse Gary
Department of Biomedical Engineering, Brown University, Providence, Rhode Island, USA.
Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Heart Asia. 2018 Jan 7;10(1):e010970. doi: 10.1136/heartasia-2017-010970. eCollection 2018.
Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.
PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.
A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I: 84%).
Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.
癌抗原125（Ca-125）传统上被认为是一种肿瘤标志物，其在心血管疾病中的作用直到近年来才得到研究。心房颤动（AF）患者的Ca-125是否升高及其水平能否预测AF风险仍存在争议。因此，我们对Ca-125水平与AF之间的关联进行了系统评价和荟萃分析。
检索PubMed和EMBASE数据库至2017年6月1日，查找评估Ca-125与AF之间关联的研究。纳入标准包括比较有AF和无AF患者的Ca-125的研究，或报告按Ca-125水平分层AF风险的HRs/ORs的研究。
从数据库中总共检索到39条记录，其中10项研究纳入最终的荟萃分析。与窦性心律患者相比，AF患者的Ca-125显著更高（平均差异=16 U/mL，95%CI 2至30 U/mL，P<0.05；I²：98%）。Ca-125显著增加AF风险（HR：1.39，95%CI 1.06至1.82，P<0.05；I²：84%）。
AF患者的Ca-125显著高于窦性心律患者，高Ca-125可预测AF的发生。然而，观察到的高异质性意味着Ca-125与AF之间的关系存在不确定性，这需要通过更大规模的前瞻性研究来证实。
