a Department of Basic and Clinical Neuroscience , King's College London , London , UK.
Autophagy. 2018;14(4):722-723. doi: 10.1080/15548627.2018.1434372. Epub 2018 Mar 13.
Macroautophagy/autophagy influences onset and progression of several human neurodegenerative diseases, because of its critical role as a regulator of neuronal proteostasis and organelle quality control. In many neurodegenerative diseases, impairment in autophagy is thought to play a fundamental part in the terminal phases of cellular degeneration and death. However, the ultimate mechanism of neuronal cell death remains elusive. In a recent study we have identified a new form of regulated cell death, which arises upon autophagy inhibition.
自噬/巨自噬影响多种人类神经退行性疾病的发病和进展，因为它作为神经元蛋白稳态和细胞器质量控制的调节剂起着关键作用。在许多神经退行性疾病中，自噬功能障碍被认为在细胞退化和死亡的终末阶段起着根本性作用。然而，神经元细胞死亡的最终机制仍难以捉摸。在最近的一项研究中，我们发现了一种新的受调控的细胞死亡形式，它是在自噬抑制时出现的。
