Beaudry Rhys I, Liang Yuanyuan, Boyton Steven T, Tucker Wesley J, Brothers R Matthew, Daniel Kathryn M, Rao Roshni, Haykowsky Mark J
1 The University of Texas at Arlington, Arlington, TX, USA.
2 University of Maryland School of Medicine, Baltimore, MD, USA.
Integr Cancer Ther. 2018 Jun;17(2):192-199. doi: 10.1177/1534735418756193. Epub 2018 Feb 2.
Cancer and cardiovascular disease (CVD) are leading causes of morbidity and mortality in the United States. Vascular endothelial dysfunction, an important contributor in the development of CVD, improves with exercise training in patients with CVD. However, the role of regular exercise to improve vascular function in cancer survivors remains equivocal. We performed a meta-analysis to determine the effect of exercise training on vascular endothelial function in cancer survivors. We searched PubMed (1975 to 2016), EMBASE CINAHL (1937 to 2016), OVID MEDLINE (1948 to 2016), and Cochrane Central Registry of Controlled Trials (1991 to 2016) using search terms: vascular function, endothelial function, flow-mediated dilation [FMD], reactive hyperemia, exercise, and cancer. Studies selected were randomized controlled trials of exercise training on vascular endothelial function in cancer survivors. We calculated pooled effect sizes and performed a meta-analysis. We identified 4 randomized controlled trials (breast cancer, n=2; prostate cancer, n=2) measuring vascular endothelial function by FMD (n=3) or reactive hyperemia index (n=1), including 163 cancer survivors (exercise training, n=82; control, n=81). Aerobic exercise training improved vascular function (n=4 studies; standardized mean difference [95% CI]=0.65 [0.33, 0.96], I=0%; FMD, weighted mean difference [WMD]=1.28 [0.22, 2.34], I=23.2%) and peak exercise oxygen uptake (3 trials; WMD [95% CI]=2.22 [0.83, 3.61] mL/kg/min; I=0%). Our findings indicate that exercise training improves vascular endothelial function and exercise capacity in breast and prostate cancer survivors.
癌症和心血管疾病（CVD）是美国发病和死亡的主要原因。血管内皮功能障碍是CVD发生发展的一个重要因素，在CVD患者中，运动训练可改善血管内皮功能障碍。然而，规律运动对改善癌症幸存者血管功能的作用仍不明确。我们进行了一项荟萃分析，以确定运动训练对癌症幸存者血管内皮功能的影响。我们检索了PubMed（1975年至2016年）、EMBASE CINAHL（1937年至2016年）、OVID MEDLINE（1948年至2016年）以及Cochrane对照试验中央注册库（1991年至2016年），使用的检索词为：血管功能、内皮功能、血流介导的血管舒张[FMD]、反应性充血、运动和癌症。入选的研究为关于癌症幸存者运动训练对血管内皮功能影响的随机对照试验。我们计算了合并效应量并进行了荟萃分析。我们确定了4项随机对照试验（乳腺癌，n = 2；前列腺癌，n = 2），通过FMD（n = 3）或反应性充血指数（n = 1）测量血管内皮功能，包括163名癌症幸存者（运动训练组，n = 82；对照组，n = 81）。有氧运动训练改善了血管功能（n = 4项研究；标准化均数差[95%CI]=0.65[0.33, 0.96]，I = 0%；FMD，加权均数差[WMD]=1.28[0.22, 2.34]，I = 23.2%）以及运动峰值摄氧量（3项试验；WMD[95%CI]=2.22[0.83, 3.61]mL/kg/min；I = 0%）。我们的研究结果表明，运动训练可改善乳腺癌和前列腺癌幸存者的血管内皮功能和运动能力。
