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基于多巴胺的材料在癌症诊断和治疗中的最新进展。

Recent developments in dopamine-based materials for cancer diagnosis and therapy.

机构信息

College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.

Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Adv Colloid Interface Sci. 2018 Feb;252:1-20. doi: 10.1016/j.cis.2018.01.001. Epub 2018 Jan 31.

Abstract

Dopamine-based materials are emerging as novel biomaterials and have attracted considerable interests in the fields of biosensing, bioimaging and cancer therapy due to their unique physicochemical properties, such as versatile adhesion property, high chemical reactivity, excellent biocompatibility and biodegradability, strong photothermal conversion capacity, etc. In this review, we present an overview of recent research progress on dopamine-based materials for diagnosis and therapy of cancer. The review starts with a summary of the physicochemical properties of dopamine-based materials in general. Then detailed description is followed on their applications in the fields of diagnosis and treatment of cancers. The review concludes with an outline of some remaining challenges for dopamine-based materials to be used for clinical applications.

摘要

基于多巴胺的材料作为新型生物材料,由于其独特的物理化学性质,如多功能的粘附性能、高化学反应性、优异的生物相容性和可生物降解性、较强的光热转换能力等,在生物传感、生物成像和癌症治疗等领域引起了相当大的关注。本综述介绍了基于多巴胺的材料在癌症诊断和治疗方面的最新研究进展。综述首先概述了一般的基于多巴胺的材料的物理化学性质。然后详细描述了它们在癌症诊断和治疗领域的应用。最后,概述了基于多巴胺的材料用于临床应用所面临的一些挑战。

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