从软木木质素中可持续生产盐酸多巴胺。
Sustainable production of dopamine hydrochloride from softwood lignin.
机构信息
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Longpan Road 159, 210037, Nanjing, China.
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Research Institute of Industrial Catalysis, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 200237, Shanghai, China.
出版信息
Nat Commun. 2023 Aug 17;14(1):4996. doi: 10.1038/s41467-023-40702-2.
Dopamine is not only a widely used commodity pharmaceutical for treating neurological diseases but also a highly attractive base for advanced carbon materials. Lignin, the waste from the lignocellulosic biomass industry, is the richest source of renewable aromatics on earth. Efficient production of dopamine direct from lignin is a highly desirable target but extremely challenging. Here, we report an innovative strategy for the sustainable production of dopamine hydrochloride from softwood lignin with a mass yield of 6.4 wt.%. Significantly, the solid dopamine hydrochloride is obtained by a simple filtration process in purity of 98.0%, which avoids the tedious separation and purification steps. The approach begins with the acid-catalyzed depolymerization, followed by deprotection, hydrogen-borrowing amination, and hydrolysis of methoxy group, transforming lignin into dopamine hydrochloride. The technical economic analysis predicts that this process is an economically competitive production process. This study fulfills the unexplored potential of dopamine hydrochloride synthesis from lignin.
多巴胺不仅是一种广泛用于治疗神经疾病的商品药物，也是高级碳材料的极具吸引力的基础物质。木质素是木质纤维素生物质工业的废弃物，是地球上最丰富的可再生芳烃资源。直接从木质素高效生产多巴胺是一个非常理想的目标，但极具挑战性。在这里，我们报告了一种从软木木质素中可持续生产盐酸多巴胺的创新策略，其质量产率为 6.4wt%。重要的是，通过简单的过滤过程可以获得纯度为 98.0%的固体盐酸多巴胺，避免了繁琐的分离和纯化步骤。该方法首先进行酸催化解聚，然后进行脱保护、氢借氨化和甲氧基水解，将木质素转化为盐酸多巴胺。技术经济分析预测，该工艺是一种具有经济竞争力的生产工艺。本研究实现了从木质素合成盐酸多巴胺这一未被探索的潜力。
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