Castro Jean Franco, Razmilic Valeria, Gomez-Escribano Juan Pablo, Andrews Barbara, Asenjo Juan, Bibb Mervyn
Department of Chemical Engineering and Biotechnology, Centre for Biotechnology and Bioengineering (CeBiB), Universidad de Chile, Beauchef 851, Santiago, Chile.
Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, NR4 7UH, Norwich, UK.
Antonie Van Leeuwenhoek. 2018 Aug;111(8):1433-1448. doi: 10.1007/s10482-018-1034-8. Epub 2018 Feb 3.
Streptomyces leeuwenhoekii strains C34, C38, C58 and C79 were isolated from a soil sample collected from the Chaxa Lagoon, located in the Salar de Atacama in northern Chile. These streptomycetes produce a variety of new specialised metabolites with antibiotic, anti-cancer and anti-inflammatory activities. Moreover, genome mining performed on two of these strains has revealed the presence of biosynthetic gene clusters with the potential to produce new specialised metabolites. This review focusses on this new clade of Streptomyces strains, summarises the literature and presents new information on strain C34.
里氏链霉菌菌株C34、C38、C58和C79是从智利北部阿塔卡马盐沼查卡湖采集的土壤样本中分离出来的。这些链霉菌产生了多种具有抗生素、抗癌和抗炎活性的新型特殊代谢产物。此外，对其中两个菌株进行的基因组挖掘表明，存在有可能产生新型特殊代谢产物的生物合成基因簇。本综述聚焦于这一新的链霉菌菌株分支，总结相关文献，并呈现关于菌株C34的新信息。
