Güneş Serkan, Ekinci Özalp, Teke Halenur, Yıldırım Veli
Department of Child and Adolescent Psychiatry, Hatay State Hospital, Hatay, Turkey.
Department of Child and Adolescent Psychiatry, Mersin University School of Medicine, Mersin, Turkey.
Clin Psychopharmacol Neurosci. 2018 Feb 28;16(1):118-121. doi: 10.9758/cpn.2018.16.1.118.
Raynaud's phenomenon is a recurrent vasospastic condition with reducing in peripheral blood flow due to cold, or emotional stress. White, blue and red discolorations occur during the attacks. Serotonin reuptake inhibitors, psychostimulants, and aripiprazole are reported to be related with Raynaud's phenomenon. Risperidone is an atypical antipsychotic drug with dopaminergic and serotonergic effects. In children and adolescents, risperidone is used for bipolar disorder, tic disorders, conduct disorder, schizophrenia, symptoms of irritability and self-mutilation. Here we report a case of Raynaud's phenomenon associated with risperidone in a 12-year-old boy. Raynaud's phenomenon occurred two weeks after starting risperidone and disappeared after stopping risperidone.
雷诺现象是一种反复发作的血管痉挛性疾病，由于寒冷或情绪应激导致外周血流减少。发作期间会出现皮肤苍白、发蓝和发红。据报道，血清素再摄取抑制剂、精神兴奋剂和阿立哌唑与雷诺现象有关。利培酮是一种具有多巴胺能和血清素能作用的非典型抗精神病药物。在儿童和青少年中，利培酮用于治疗双相情感障碍、抽动障碍、品行障碍、精神分裂症、易怒和自残症状。在此，我们报告一名12岁男孩出现与利培酮相关的雷诺现象的病例。服用利培酮两周后出现雷诺现象，停药后消失。
