Lou Li-Li, Zhao Peng, Cheng Zhuo-Yang, Guo Rui, Yao Guo-Dong, Wang Xiao-Bo, Huang Xiao-Xiao, Song Shao-Jiang
a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , People's Republic of China.
b Chinese People's Liberation Army 210 Hospital , Dalian , People's Republic of China.
Nat Prod Res. 2019 Jun;33(12):1791-1793. doi: 10.1080/14786419.2018.1434646. Epub 2018 Feb 4.
In this study, a new coumarin, juglansoside C () was isolated from the bark of . Its chemical structure was identified by comprehensive spectroscopic analyses. The cytotoxicity assay showed that exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that markedly induced apoptosis in Hep3B cells.
在本研究中，从[植物名称]的树皮中分离出一种新的香豆素——胡桃苷C（）。通过综合光谱分析确定了其化学结构。细胞毒性试验表明，其对人肝癌Hep3B细胞表现出中等细胞毒性，IC值为70.9 μM。此外，Annexin V-FITC/PI染色试验表明，其显著诱导Hep3B细胞凋亡。
