Banikazemi Zarrin, Mirazimi Seyed Mohammad, Dashti Fatemeh, Mazandaranian Mohammad Reza, Akbari Maryam, Morshedi Korosh, Aslanbeigi Fatemeh, Rashidian Amir, Chamanara Mohsen, Hamblin Michael R, Taghizadeh Mohsen, Mirzaei Hamed
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Front Oncol. 2021 Oct 11;11:752784. doi: 10.3389/fonc.2021.752784. eCollection 2021.
Cancers of the gastrointestinal (GI) tract are often life-threatening malignancies, which can be a severe burden to the health care system. Globally, the mortality rate from gastrointestinal tumors has been increasing due to the lack of adequate diagnostic, prognostic, and therapeutic measures to combat these tumors. Coumarin is a natural product with remarkable antitumor activity, and it is widely found in various natural plant sources. Researchers have explored coumarin and its related derivatives to investigate their antitumor activity, and the potential molecular mechanisms involved. These mechanisms include hormone antagonists, alkylating agents, inhibitors of angiogenesis, inhibitors of topoisomerase, inducers of apoptosis, agents with antimitotic activity, telomerase inhibitors, inhibitors of human carbonic anhydrase, as well as other potential mechanisms. Consequently, drug design and discovery scientists and medicinal chemists have collaborated to identify new coumarin-related agents in order to produce more effective antitumor drugs against GI cancers. Herein, we summarize the therapeutic effects of coumarin and its derivatives against GI cancer.
胃肠道（GI）癌症通常是危及生命的恶性肿瘤，会给医疗保健系统带来沉重负担。在全球范围内，由于缺乏足够的诊断、预后和治疗措施来对抗这些肿瘤，胃肠道肿瘤的死亡率一直在上升。香豆素是一种具有显著抗肿瘤活性的天然产物，广泛存在于各种天然植物来源中。研究人员已对香豆素及其相关衍生物进行探索，以研究它们的抗肿瘤活性以及潜在的分子机制。这些机制包括激素拮抗剂、烷基化剂、血管生成抑制剂、拓扑异构酶抑制剂、凋亡诱导剂、具有抗有丝分裂活性的药物、端粒酶抑制剂、人碳酸酐酶抑制剂以及其他潜在机制。因此，药物设计与发现科学家和药物化学家合作，以鉴定新的香豆素相关药物，从而生产出更有效的抗胃肠道癌症的抗肿瘤药物。在此，我们总结香豆素及其衍生物对胃肠道癌症的治疗作用。
