Austin Evan, Huang Amy, Adar Tony, Wang Erica, Jagdeo Jared
Dermatology Service, Sacramento VA Medical Center, Mather, California.
Department of Dermatology, University of California at Davis, Sacramento, California.
Lasers Surg Med. 2018 Feb 5. doi: 10.1002/lsm.22794.
Our skin is constantly exposed to light from solar radiation and electronic devices, which impact skin physiology and aging. The biological altering properties of ultraviolet (UV) solar radiation on skin have been well established. There is significant scientific and public interest on the effects of electronic device generated light (EDGL) on skin. Currently, the effects of EDGL on skin are largely unknown. EDGL includes UV, visible, and infrared light from consumer electronics such as smartphones, computers, and televisions. In this study, we measured the wavelength specific irradiance from electronic devices, and irradiated fibroblasts with white EDGL to determine changes in reactive oxygen species generation, apoptosis, and necrosis.
To determine the EDGL output of commonly used consumer electronic devices, we measured the irradiance from electronic devices at the manufacturers' recommended reading distances and at 1 cm. To determine the effect of EDGL on human skin cells, we irradiated AG13145 fibroblasts with EDGL for 1 hour at a distance of 1 cm and measured changes in reactive oxygen species generation, apoptosis, and necrosis.
ROS increased significantly by 81.71%, 85.79%, and 92.98% relative to control following 1 hour of white EDGL from iPhone 8+, iPhone 6, and iPad (first generation), respectively. There was a non-significant change in apoptosis following irradiation with an iPhone 8+, iPhone 6, and iPad. Total necrosis was less than 2% for all treatment and control groups.
Our results suggest that short exposures of EDGL increase ROS generation, but the long-term effects associated with repeated exposures of EDGL are unknown. As electronic devices become more widely used and integrated into society globally, we anticipate greater scientific research and general public interest on the effects of visible EDGL on skin. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.
我们的皮肤持续暴露于太阳辐射和电子设备发出的光下，这会影响皮肤生理和老化。紫外线（UV）太阳辐射对皮肤的生物学改变特性已得到充分证实。电子设备产生的光（EDGL）对皮肤的影响引起了科学界和公众的极大兴趣。目前，EDGL对皮肤的影响在很大程度上尚不清楚。EDGL包括来自智能手机、电脑和电视等消费电子产品的紫外线、可见光和红外线。在本研究中，我们测量了电子设备发出的特定波长辐照度，并用白色EDGL照射成纤维细胞，以确定活性氧生成、细胞凋亡和坏死的变化。
为了确定常用消费电子设备的EDGL输出，我们在制造商推荐的阅读距离和1厘米处测量了电子设备的辐照度。为了确定EDGL对人类皮肤细胞的影响，我们在1厘米的距离用EDGL照射AG13145成纤维细胞1小时，并测量活性氧生成、细胞凋亡和坏死的变化。
相对于对照组，分别用iPhone 8 +、iPhone 6和第一代iPad的白色EDGL照射1小时后，活性氧分别显著增加了81.71%、85.79%和92.98%。用iPhone 8 +、iPhone 6和iPad照射后，细胞凋亡无显著变化。所有治疗组和对照组的总坏死率均小于2%。
我们的结果表明，短时间暴露于EDGL会增加活性氧的生成，但与反复暴露于EDGL相关的长期影响尚不清楚。随着电子设备在全球范围内越来越广泛地使用并融入社会，我们预计关于可见EDGL对皮肤影响的科学研究和公众关注度会更高。激光外科医学。©2018威利期刊公司
