Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
J Gynecol Oncol. 2018 Mar;29(2):e24. doi: 10.3802/jgo.2018.29.e24. Epub 2017 Dec 27.
To examine trends and characteristics of single women with malignancy of the uterine cervix.
This is a retrospective observational study examining the United States population-based tumor registry (the Surveillance, Epidemiology, and End Results program). Time-specific trends in single marital status were examined in 3,294,208 women among 12 common female malignancies including 87,151 women with uterine cervical malignancy between 1973 and 2013.
While the proportion of single women in the majority of malignancies increased during the study time, the proportion of single women with cervical malignancy significantly increased more than in other malignancies (29.3% in 2013 from 6.3% in 1973). There was a surge in the proportion of single women with cervical malignancy starting in the early 1990s, exhibiting the largest annual percentage rate change (APC) among all examined malignancies (1.8%; 95% confidence interval [CI]=1.6, 2.0; p<0.001). There was a significant decrease in the proportion of women aged <40 years with cervical malignancy between 1989 and 2013 (APC, -1.2%; 95% CI=-1.4, -1.0; p<0.001). However, when stratified by age, the proportion of single women aged ≥40 years increased significantly during the time (APC, 2.7%; 95% CI=2.3, 3.2; p<0.001) but did not in those who were <40 years (APC, 0.1%; 95% CI=-0.7, 0.6; p=0.850).
The proportion of single women with malignancy of the uterine cervix has significantly increased in the past 4 decades. This increase was most dramatic in single women aged ≥40 years. Improving screening strategies in single women aged ≥40 years may help reduce the incidence of this malignancy.
研究子宫颈恶性肿瘤单身女性的趋势和特征。
这是一项回顾性观察性研究，对基于美国人群的肿瘤登记处（监测、流行病学和最终结果计划）进行了检查。在 1973 年至 2013 年间，对 12 种常见女性恶性肿瘤中的 3,294,208 名女性进行了特定时间的单一婚姻状况趋势检查，其中包括 87,151 名患有子宫颈恶性肿瘤的女性。
虽然在研究期间，大多数恶性肿瘤中单身女性的比例有所增加，但患有宫颈癌的单身女性比例增长幅度明显大于其他恶性肿瘤（1973 年为 6.3%，2013 年为 29.3%）。从 20 世纪 90 年代初开始，宫颈癌单身女性的比例出现激增，是所有检查的恶性肿瘤中年度百分比变化率（APC）最大的（1.8%；95%置信区间[CI]=1.6，2.0；p<0.001）。1989 年至 2013 年，年龄<40 岁患有宫颈癌的女性比例显著下降（APC，-1.2%；95% CI=-1.4，-1.0；p<0.001）。但是，按年龄分层时，年龄≥40 岁的单身女性比例在这段时间内显著增加（APC，2.7%；95% CI=2.3，3.2；p<0.001），而年龄<40 岁的单身女性比例没有增加（APC，0.1%；95% CI=-0.7，0.6；p=0.850）。
在过去的 40 年中，患有子宫颈恶性肿瘤的单身女性比例显著增加。在年龄≥40 岁的单身女性中，这种增长最为明显。改善年龄≥40 岁单身女性的筛查策略可能有助于降低这种恶性肿瘤的发病率。
