Department of Pediatric Endocrinology, Ankara Children's Hematology and Oncology Training Hospital, Ankara, Turkey.
Department of Biochemistry, Atatürk Training and Research Hospital, Ankara, Turkey.
Med Princ Pract. 2018;27(1):44-48. doi: 10.1159/000487138. Epub 2018 Jan 25.
To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism (SHT).
Thiol/disulphide homeosta sis, involving native thiol (SH), disulphide (SS), and total thiol (SS + SH), was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a thyroid-stimulating hormone (TSH) value of > 5 mIU/L, and in 40 sex- and age-matched healthy control subjects who were negative for thyroid autoantibodies and had normal TSH levels. Lipid profiles and urine iodine levels were also determined.
SH (466 ± 32.8 vs. 462 ± 32.1 μmol/L p = 0.59), SH + SS (508 ± 34.0 vs. 506 ± 32.7 μmol/L, p = 0.81), SS (21 ± 5.5 vs. 22 ± 5.8 μmol/L, p = 0.41), SS/SH (4.5 ± 1.2 vs. 4.8 ± 1.3%, p = 0.36), SS/SH + SS (4.1 ± 1.0 vs. 4.3 ± 1.1%, p = 0.36) and SH/SH + SS (91 ± 2.1 vs. 91 ± 2.1%, p = 0.31) levels were similar in children with SHT and control subjects (p > 0.05). There was no difference between total cholesterol, triglyceride, and low-density lipoprotein levels in SHT patients and controls. No difference was detected between the patients with or without iodine deficiency in the SHT group in terms of thiol/disulphide homeostasis parameters.
The status of dynamic thiol/disulphide homeostasis did not change in children and adolescents with non-autoimmune SHT. Future studies are needed for the evaluation of oxidative stress in patients with long-standing non-autoimmune SHT.
评估非自身免疫亚临床甲状腺功能减退症（SHT）儿童的硫醇/二硫键稳态。
评估 60 名儿童和青少年的硫醇/二硫键稳态，这些儿童和青少年的甲状腺自身抗体（抗甲状腺过氧化物酶、抗甲状腺球蛋白）为阴性，促甲状腺激素（TSH）值>5mIU/L，40 名性别和年龄匹配的健康对照组的甲状腺自身抗体为阴性，促甲状腺激素水平正常。还测定了血脂谱和尿碘水平。
SH（466±32.8 vs. 462±32.1 μmol/L，p=0.59）、SH+SS（508±34.0 vs. 506±32.7 μmol/L，p=0.81）、SS（21±5.5 vs. 22±5.8 μmol/L，p=0.41）、SS/SH（4.5±1.2 vs. 4.8±1.3%，p=0.36）、SS/SH+SS（4.1±1.0 vs. 4.3±1.1%，p=0.36）和 SH/SH+SS（91±2.1 vs. 91±2.1%，p=0.31）在 SHT 患儿和对照组之间无差异（p>0.05）。SHT 患儿和对照组之间的总胆固醇、甘油三酯和低密度脂蛋白水平无差异。SHT 组中存在碘缺乏的患者与不存在碘缺乏的患者之间的硫醇/二硫键稳态参数无差异。
非自身免疫性 SHT 儿童和青少年的动态硫醇/二硫键稳态没有改变。需要进一步研究长期非自身免疫性 SHT 患者的氧化应激情况。
