尼日利亚西北部卡诺市阿明努·卡诺教学医院接受抗逆转录病毒治疗的人类免疫缺陷病毒阳性孕妇的血液学参数

Hematological parameters of human immunodeficiency virus positive pregnant women on antiretroviral therapy in Aminu Kano Teaching Hospital Kano, North Western Nigeria.

作者信息

Abdulqadir Ibrahim, Ahmed Sagir Gumel, Kuliya Aisha Gwarzo, Tukur Jamilu, Yusuf Aminu Abba, Musa Abubakar Umar

机构信息

Department of Haematology and Blood Transfusion, UDUTH, Sokoto, Nigeria.

Department of Haematology and Blood Transfusion, Aminu Kano Teaching Hospital, Kano, Nigeria.

出版信息

J Lab Physicians. 2018 Jan-Mar;10(1):60-63. doi: 10.4103/JLP.JLP_80_17.

DOI:10.4103/JLP.JLP_80_17

PMID:29403207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5784296/

Abstract

CONTEXT

Human immunodeficiency virus (HIV) scourge continues to affect young women within the reproductive age group and pregnancy is a recognized indication for the use antiretroviral (ARV) drugs among HIV-positive women.

AIMS

The aim is to determine the combined effect of pregnancy, HIV and ARV drugs on the hematological parameters of the pregnant women.

SETTINGS AND DESIGN

This was a comparative cross-sectional study conducted among 70 each of HIV-positive and negative pregnant women.

SUBJECTS AND METHODS

Bio-demographic and clinical data were extracted from the client folder and 4 ml of blood sample was obtained from each participant. Full blood count was generated using Swelab automatic hematology analyzer while reticulocyte count and erythrocyte sedimentation rate (ESR) were conducted manually.

STATISTICAL ANALYSIS USED

Data analysis was performed using SPSS version software 16 while < 0.05 was considered statistically significant.

RESULTS

Pregnant women with HIV had statistically significant lower hematocrit and white blood cell (WBC) and higher ESR than pregnant women without HIV ( < 0.000). There was no statistically significant difference between the two groups in terms of platelet and reticulocyte ( > 0.05). However, among HIV positive pregnant women, those with CD4 count <350/μL had statistically significant lower WBC and lymphocyte count than those with CD4 count ≥350/μL ( < 0.05), whereas, those on zidovudine (AZT)-containing treatment had statistically significant lower hematocrit and higher mean cell volume than those on non-AZT-containing treatment ( < 0.05), but there was no statistically significant difference in any of the hematological parameters ( > 0.050) between women on first- and second-line ARV regimens.

CONCLUSIONS

There is a significant difference in terms of hematological parameters between HIV-positive and HIV-negative pregnant women in this environment.

摘要

背景

人类免疫缺陷病毒（HIV）的祸害继续影响育龄期年轻女性，怀孕是HIV阳性女性使用抗逆转录病毒（ARV）药物的公认指征。

目的

目的是确定怀孕、HIV和ARV药物对孕妇血液学参数的综合影响。

设置与设计

这是一项比较性横断面研究，对70名HIV阳性和70名HIV阴性孕妇进行了研究。

研究对象与方法

从患者病历中提取生物人口统计学和临床数据，并从每位参与者身上采集4毫升血液样本。使用Swelab自动血液分析仪进行全血细胞计数，同时手工进行网织红细胞计数和红细胞沉降率（ESR）检测。

所用统计分析方法

使用SPSS 16版软件进行数据分析，P<0.05被认为具有统计学意义。

结果

与未感染HIV的孕妇相比，感染HIV的孕妇血细胞比容和白细胞（WBC）在统计学上显著降低，ESR更高（P<0.000）。两组在血小板和网织红细胞方面无统计学显著差异（P>0.05）。然而，在HIV阳性孕妇中，CD4细胞计数<350/μL的孕妇白细胞和淋巴细胞计数在统计学上显著低于CD4细胞计数≥350/μL的孕妇（P<0.05）；而接受含齐多夫定（AZT）治疗的孕妇血细胞比容在统计学上显著低于接受不含AZT治疗的孕妇，平均红细胞体积更高（P<0.05），但一线和二线ARV治疗方案的女性在任何血液学参数上均无统计学显著差异（P>0.050）。