Kim Donghee, Jun Hee-Sook
Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, South Korea.
College of Pharmacy, Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, South Korea.
Front Endocrinol (Lausanne). 2018 Jan 22;8:382. doi: 10.3389/fendo.2017.00382. eCollection 2017.
The beta-cells in the islets of Langerhans in the pancreas secrete insulin and play an important role in glucose homeostasis. Diabetes, characterized by hyperglycemia, results from an absolute or a relative deficiency of the pancreatic beta-cell mass. Islet transplantation has been considered to be a useful therapeutic approach, but it is largely unsuccessful because most of the transplanted islets are lost in the early stage of transplantation. To evaluate the efficacy of intervention methods for the improvement of islet survival, monitoring of the functional islet mass is needed. Various techniques to image and track transplanted islets have been investigated to assess islets after transplantation. In this review, recent progresses in imaging methods to visualize islets are discussed.
胰腺中胰岛的β细胞分泌胰岛素，并在葡萄糖稳态中发挥重要作用。以高血糖为特征的糖尿病是由胰腺β细胞数量的绝对或相对不足引起的。胰岛移植被认为是一种有用的治疗方法，但在很大程度上并不成功，因为大多数移植的胰岛在移植早期就丢失了。为了评估改善胰岛存活的干预方法的疗效，需要监测功能性胰岛质量。已经研究了各种对移植胰岛进行成像和追踪的技术，以评估移植后的胰岛。在这篇综述中，将讨论用于可视化胰岛的成像方法的最新进展。
