印度尼西亚巴厘岛和松巴哇岛新型大鼠戊型肝炎病毒株的鉴定与特性分析。
The identification and characterization of novel rat hepatitis E virus strains in Bali and Sumbawa, Indonesia.
作者信息
Primadharsini Putu Prathiwi, Wibawa I Dewa Nyoman, Anggoro Joko, Nishizawa Tsutomu, Takahashi Masaharu, Jirintai Suljid, Okamoto Hiroaki
机构信息
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
West Nusa Tenggara Hepatitis Laboratory, Mataram, Indonesia.
出版信息
Arch Virol. 2018 May;163(5):1345-1349. doi: 10.1007/s00705-018-3736-7. Epub 2018 Feb 5.
All three genetic groups of ratHEV have been found in Indonesia, suggesting the presence of additional variants of ratHEV in unexamined areas of Indonesia. A total of 242 wild rats were captured in Bali and Sumbawa, Indonesia, during 2014-2016. Among them, 4.1% were seropositive for anti-ratHEV IgG and two (0.8%) had detectable ratHEV RNA: ratESUMBAWA-140L and ratEBali2016D-047L, sharing 84.9-85.4% and 86.9-92.1% nucleotide identity with the reported G2 strains, respectively. The provisional criteria supported the notion that the ratEBali2016D-047L and ratESUMBAWA-140L strains were novel G2 variants. These results suggested the spatial distribution of further divergent ratHEV strains in Indonesia.
在印度尼西亚已发现大鼠戊型肝炎病毒（ratHEV）的所有三个基因群，这表明在印度尼西亚未检测地区存在ratHEV的其他变体。2014年至2016年期间，在印度尼西亚的巴厘岛和松巴哇岛共捕获了242只野生大鼠。其中，4.1%的大鼠抗ratHEV IgG血清呈阳性，两只（0.8%）检测到ratHEV RNA：ratESUMBAWA-140L和ratEBali2016D-047L，它们与已报道的G2株分别具有84.9 - 85.4%和86.9 - 92.1%的核苷酸同一性。临时标准支持ratEBali2016D-047L和ratESUMBAWA-140L菌株是新型G2变体这一观点。这些结果表明在印度尼西亚存在进一步分化的ratHEV菌株的空间分布。
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