National Exposure Research Laboratory, Office of Research and Development , U.S. Environmental Protection Agency , 109 T. W. Alexander Drive , Research Triangle Park , North Carolina 27711 , United States.
Southwest Research Institute , San Antonio , Texas 78238 , United States.
Environ Sci Technol. 2018 Mar 6;52(5):3125-3135. doi: 10.1021/acs.est.7b04781. Epub 2018 Feb 26.
A two-dimensional gas chromatography-time-of-flight/mass spectrometry (GC×GC-TOF/MS) suspect screening analysis method was used to rapidly characterize chemicals in 100 consumer products-which included formulations (e.g., shampoos, paints), articles (e.g., upholsteries, shower curtains), and foods (cereals)-and therefore supports broader efforts to prioritize chemicals based on potential human health risks. Analyses yielded 4270 unique chemical signatures across the products, with 1602 signatures tentatively identified using the National Institute of Standards and Technology 2008 spectral database. Chemical standards confirmed the presence of 119 compounds. Of the 1602 tentatively identified chemicals, 1404 were not present in a public database of known consumer product chemicals. Reported data and model predictions of chemical functional use were applied to evaluate the tentative chemical identifications. Estimated chemical concentrations were compared to manufacturer-reported values and other measured data. Chemical presence and concentration data can now be used to improve estimates of chemical exposure, and refine estimates of risk posed to human health and the environment.
采用二维气相色谱-飞行时间/质谱联用（GC×GC-TOF/MS）可疑筛查分析方法，快速分析了 100 种消费品中的化学物质，包括配方（如洗发水、油漆）、物品（如家具、浴帘）和食品（谷物），从而支持了根据潜在人类健康风险对化学品进行优先排序的更广泛努力。分析得出了产品中 4270 种独特的化学特征，使用国家标准与技术研究院 2008 年光谱数据库对 1602 种特征进行了初步鉴定。化学标准证实了 119 种化合物的存在。在已知消费品化学物质的公共数据库中，1602 种初步鉴定的化学品中有 1404 种不存在。报告的数据和化学功能使用模型预测被用于评估初步的化学鉴定。估计的化学浓度与制造商报告的值和其他测量数据进行了比较。化学物质的存在和浓度数据现在可用于改善化学暴露的估计，并改进对人类健康和环境构成的风险的估计。
