胆红素在肝脏-肠道信号轴中的作用。
Bilirubin in the Liver-Gut Signaling Axis.
机构信息
Center for Hypertension and Personalized Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA.
Department of Physiology & Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, USA.
出版信息
Trends Endocrinol Metab. 2018 Mar;29(3):140-150. doi: 10.1016/j.tem.2018.01.002. Epub 2018 Feb 3.
Abstract
Bilirubin is a component of the heme catabolic pathway that is essential for liver function and has been shown to reduce hepatic fat accumulation. High plasma bilirubin levels are reflective of liver disease due to an injurious effect on hepatocytes. In healthy liver, bilirubin is conjugated and excreted to the intestine and converted by microbes to urobilinoids, which are reduced to the predominant pigment in feces, stercobilin, or reabsorbed. The function of urobilinoids in the gut or their physiological relevance of reabsorption is not well understood. In this review, we discuss the relationship of hepatic bilirubin signaling to the intestinal microbiota and its regulation of the liver-gut axis, as well as its capacity to mediate these processes.
摘要
胆红素是血红素代谢途径的一个组成部分，对于肝功能至关重要，并已被证明可以减少肝内脂肪堆积。由于对肝细胞有损伤作用，高血浆胆红素水平反映了肝脏疾病。在健康的肝脏中，胆红素被结合并排泄到肠道，并被微生物转化为尿胆素原，然后被还原为粪便中的主要色素粪胆素或被重吸收。尿胆素原在肠道中的功能或其被重吸收的生理相关性尚不清楚。在这篇综述中，我们讨论了肝内胆红素信号与肠道微生物群的关系及其对肝肠轴的调节作用，以及它介导这些过程的能力。
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