Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Pathog Dis. 2021 May 11;79(5). doi: 10.1093/femspd/ftab025.
Multiple species of obligate intracellular bacteria in the genus Chlamydia are important veterinary and/or human pathogens. These pathogens all share similar biphasic developmental cycles and transition between intracellular vegetative reticulate bodies and infectious elementary forms, but vary substantially in their host preferences and pathogenic potential. A lack of tools for genetic engineering of these organisms has long been an impediment to the study of their biology and pathogenesis. However, the refinement of approaches developed in C. trachomatis over the last 10 years, and adaptation of some of these approaches to other Chlamydia spp. in just the last few years, has opened exciting new possibilities for studying this ubiquitous group of important pathogens.
衣原体属中的多种专性细胞内细菌是重要的兽医和/或人类病原体。这些病原体在其宿主偏好和致病潜力上有很大的不同，但都具有相似的两相发育周期和在细胞内的营养体网状体与感染性的原体之间的转化。长期以来，缺乏这些生物体的遗传工程工具一直是研究它们的生物学和发病机制的障碍。然而，在过去 10 年中，对沙眼衣原体开发的方法的改进，以及在过去几年中，将其中一些方法适应于其他衣原体属的方法，为研究这组普遍存在的重要病原体开辟了令人兴奋的新可能性。
