Saint-Leger D, Bague A, Lefebvre E, Cohen E, Chivot M
Br J Dermatol. 1986 May;114(5):543-52. doi: 10.1111/j.1365-2133.1986.tb04061.x.
Skin surface lipids and lipids from open and closed comedones in acne patients were analysed by thin layer chromatography. The results showed that these lipids were enriched in polar lipids, as compared with the skin surface lipids obtained from controls without acne. In both open and closed comedones, these polar lipids appeared to be derived mainly from the oxidation of squalene, which is in agreement with our previous in vitro results. We suggest that squalene oxidation is the link between comedogenesis and bacterial colonization, and based on this, we propose a hypothesis of the pathogenesis of acne.
采用薄层色谱法分析了痤疮患者皮肤表面脂质以及开放性和闭合性粉刺中的脂质。结果显示，与未患痤疮的对照组获得的皮肤表面脂质相比，这些脂质富含极性脂质。在开放性和闭合性粉刺中，这些极性脂质似乎主要源自角鲨烯的氧化，这与我们之前的体外实验结果一致。我们认为角鲨烯氧化是粉刺形成与细菌定植之间的联系，并基于此提出了痤疮发病机制的假说。
