通过分子内还原镍催化立体选择性合成鬼臼木脂素核心结构。
Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis.
作者信息
Xiao Jian, Cong Xiao-Wei, Yang Gui-Zhen, Wang Ya-Wen, Peng Yu
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
出版信息
Chem Commun (Camb). 2018 Feb 20;54(16):2040-2043. doi: 10.1039/c8cc00001h.
A Ni-catalyzed reductive cascade to a diastereocontrolled construction of THN[2,3-c]furan, is developed. The mild reaction conditions led to the tolerance of broad functional groups that can be placed in almost every position of this skeleton with good yields. The conformational control for the observed trans- or cis-fused selectivity during this tandem cyclization-coupling is also proposed.
开发了一种镍催化的还原级联反应，用于非对映选择性构建THN[2,3-c]呋喃。温和的反应条件使得该反应能够耐受多种官能团，这些官能团可以以良好的产率引入到该骨架的几乎每个位置。此外，还提出了在这种串联环化-偶联过程中观察到的反式或顺式稠合选择性的构象控制。
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