通过立体选择性还原镍催化实现鬼臼毒素及其相关家族成员的发散不对称合成。
Divergent Asymmetric Syntheses of Podophyllotoxin and Related Family Members via Stereoselective Reductive Ni-Catalysis.
机构信息
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou , Gansu 730000 , China.
School of Life Science and Engineering , Southwest Jiaotong University , Chengdu 610031 , China.
出版信息
Org Lett. 2018 Mar 16;20(6):1651-1654. doi: 10.1021/acs.orglett.8b00408. Epub 2018 Mar 6.
PMID:29508607
Abstract
A nickel-catalyzed reductive cascade approach to the efficient construction of diastereodivergent cores embedded in podophyllum lignans is developed for the first time. Their gram-scale access paved the way for unified syntheses of naturally occurring podophyllotoxin and other members.
摘要
首次发展了镍催化的还原级联方法，用于有效构建具有差向异构核心的鬼臼木脂素。它们的克级合成方法为天然鬼臼毒素和其他成员的统一合成铺平了道路。
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