Department of Oral Implantology & Institute of Stomatological Research, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key laboratory of Stomatology, Sun Yat-sen University, Guangzhou, PR China.
Department of Oral Implantology & Institute of Stomatological Research, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key laboratory of Stomatology, Sun Yat-sen University, Guangzhou, PR China.
Colloids Surf B Biointerfaces. 2018 Apr 1;164:58-69. doi: 10.1016/j.colsurfb.2018.01.022. Epub 2018 Feb 3.
Osteoblast cell adhesion is the initial step of early osseointegration responding to bone material implants. Enhancing the osteoblastic cell adhesion has become one of the prime aims when optimizing the surface properties of bone biomaterials. The traditional strategy focuses in improving the physical attachment of osteoblastic cells onto the surfaces of biomaterials. However, instead of a simple cell physical attachment, the osteoblastic cell adhesion has been revealed to be a sophisticated system. Despite the well-documented effect of bone biomaterial surface modifications on adhesion, few studies have focused on the underlying molecular mechanisms. Physicochemical signals from biomaterials can be transduced into intracellular signaling network and further initiate the early response cascade towards the implants, which includes cell survival, migration, proliferation, and differentiation. Adhesion is vital in determining the early osseointegration between host bone tissue and implanted bone biomaterials via regulating involving signaling pathways. Therefore, the modulation of early adhesion behavior should not simply target in physical attachment, but emphasize in the manipulation of downstream signaling pathways, to regulate early osseointegration. This review firstly summarized the basic biological principles of osteoblastic cell adhesion process and the activated downstream cell signaling pathways. The effects of different biomaterial physicochemical properties on osteoblastic cell adhesion were then reviewed. This review provided up-to-date research outcomes in the adhesion behavior of osteoblastic cells on bone biomaterials with different physicochemical properties. The strategy is optimised from traditionally focusing in physical cell adhesion to the proposed strategy that manipulating cell adhesion and the downstream signaling network for the enhancement of early osseointegration.
成骨细胞黏附是对骨植入材料早期骨整合反应的初始步骤。增强成骨细胞黏附已成为优化骨生物材料表面性能的主要目标之一。传统策略侧重于改善成骨细胞在生物材料表面的物理附着。然而，成骨细胞黏附已被揭示为一个复杂的系统，而不仅仅是细胞的简单物理附着。尽管有大量关于骨生物材料表面修饰对黏附影响的文献，但很少有研究关注其潜在的分子机制。生物材料的物理化学信号可以转导到细胞内信号网络，并进一步引发对植入物的早期反应级联，包括细胞存活、迁移、增殖和分化。黏附在通过调节涉及的信号通路来确定宿主骨组织和植入骨生物材料之间的早期骨整合中至关重要。因此，早期黏附行为的调节不应仅仅针对物理附着，而应强调对下游信号通路的操纵，以调节早期骨整合。
本综述首先总结了成骨细胞黏附过程的基本生物学原理和激活的下游细胞信号通路。然后综述了不同生物材料物理化学性质对成骨细胞黏附的影响。本综述提供了关于具有不同物理化学性质的骨生物材料上成骨细胞黏附行为的最新研究结果。该策略从传统上侧重于物理细胞黏附优化为操纵细胞黏附和下游信号网络以增强早期骨整合的策略。
