Department of Psychology, Northeastern University, Boston, MA 02115, USA.
Curr Opin Neurobiol. 2018 Apr;49:95-98. doi: 10.1016/j.conb.2018.01.007. Epub 2018 Feb 2.
Despite ample evidence for sex differences in brain structure and function, our understanding of the neurobiological basis of behavior comes almost exclusively from male animals. As neuroscientists move to comply with recent NIH mandates that biomedical researchers include both sexes in their studies, the ways we interpret outcomes in classic rodent behavioral models deserve closer scrutiny and more nuanced evaluation. In this mini-review, we highlight recent sex differences papers in learning, decision-making, and spatial navigation paradigms that underscore the distinctions between cognitive capabilities versus behavioral strategies that may confer unique benefits to males and females.
尽管有大量证据表明大脑结构和功能存在性别差异，但我们对行为的神经生物学基础的理解几乎完全来自雄性动物。随着神经科学家们开始遵守 NIH 的最新规定，即生物医学研究人员在其研究中纳入两性，我们对经典啮齿类动物行为模型中的研究结果的解释就需要更仔细地审查和更细致的评估。在这篇迷你综述中，我们强调了最近在学习、决策和空间导航范式方面的性别差异研究，这些研究突出了认知能力与行为策略之间的区别，这些区别可能为男性和女性带来独特的益处。
