Sagnella G A, Markandu N D, Shore A C, MacGregor G A
J Hypertens Suppl. 1986 Jun;4(2):S115-8.
Plasma levels of immunoreactive atrial natriuretic peptide (irANP) have been measured in normal subjects in response to changes in sodium balance induced by either saline infusion or alterations in dietary sodium intake. In eight normotensive subjects, plasma levels of irANP (means +/- s.e.m.) increased from 5.8 +/- 0.9 to 15.8 +/- 4.4 pg/ml plasma after an infusion of isotonic saline (2 litres over a 60-min period). In seven subjects, plasma levels of irANP were measured on the 5th day of a low-sodium diet (10 mmol/day), a normal-sodium diet (150 mmol/day) and a high-sodium diet (350 mmol/day). Plasma levels of irANP increased with increasing sodium intake, with values of 4.0 +/- 0.9 (low-sodium diet), 6.9 +/- 1.3 (normal-sodium intake) and 12.1 +/- 1.8 pg/ml (high-sodium intake). These observations suggest that the atrial natriuretic peptides could be an important hormone system in the control of sodium excretion by the kidney, and thereby of sodium balance in normal man.
在正常受试者中，已测量了血浆中免疫反应性心钠素（irANP）的水平，以响应由盐水输注或饮食中钠摄入量改变所引起的钠平衡变化。在8名血压正常的受试者中，输注等渗盐水（60分钟内输注2升）后，血浆中irANP的水平（均值±标准误）从5.8±0.9 pg/ml血浆升至15.8±4.4 pg/ml血浆。在7名受试者中，分别在低钠饮食（10 mmol/天）、正常钠饮食（150 mmol/天）和高钠饮食（350 mmol/天）的第5天测量血浆中irANP的水平。血浆中irANP的水平随钠摄入量的增加而升高，低钠饮食时为4.0±0.9 pg/ml，正常钠摄入时为6.9±1.3 pg/ml，高钠摄入时为12.1±1.8 pg/ml。这些观察结果表明，心钠素可能是控制肾脏钠排泄从而控制正常人钠平衡的一个重要激素系统。
