Sagnella G A, Markandu N D, Shore A C, MacGregor G A
Lancet. 1985 Nov 30;2(8466):1208-11. doi: 10.1016/s0140-6736(85)90741-x.
Plasma levels of immunoreactive atrial natriuretic peptide (IrANP) were measured in healthy normotensive subjects before and after saline infusion and changes in dietary salt intakes. When 2 litres of 0.9% saline (308 mmol Na+) were infused over 1 h, plasma levels (mean +/- SD) of IrANP increased from 5.8 +/- 2.8 pg/ml to 15.8 +/- 12.5 pg/ml. Plasma levels on the fifth day of a low sodium diet (10 mmol/day) were 3.8 +/- 2.4 pg/ml, a normal sodium intake (150 mmol/day) 6.4 +/- 2.9 pg/ml, and a high salt intake (350 mmol/day) 12.7 +/- 6 pg/ml. These results suggest that atrial natriuretic peptides could be important hormones in the control of sodium balance in normal man.
在健康血压正常的受试者中，分别在输注生理盐水前后以及改变饮食盐摄入量后，测量了免疫反应性心房利钠肽（IrANP）的血浆水平。当在1小时内输注2升0.9%的生理盐水（308 mmol钠）时，IrANP的血浆水平（平均值±标准差）从5.8±2.8 pg/ml升高至15.8±12.5 pg/ml。低钠饮食（10 mmol/天）第5天的血浆水平为3.8±2.4 pg/ml，正常钠摄入量（150 mmol/天）时为6.4±2.9 pg/ml，高盐摄入量（350 mmol/天）时为12.7±6 pg/ml。这些结果表明，心房利钠肽可能是正常人钠平衡调节中的重要激素。
