Snodgrass Rayven, Nguyen Leonard T, Guo Maggie, Vaska Marcus, Naugler Christopher, Rashid-Kolvear Fariborz
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Calgary Laboratory Services, Calgary, AB, Canada.
BMC Res Notes. 2018 Feb 7;11(1):104. doi: 10.1186/s13104-018-3225-9.
Acute lymphocytic leukemia (ALL) is a rare malignant neoplasm that develops from abnormal lymphoid stem cells. ALL incidence is highest among children and declines towards adolescence. There is limited data on the epidemiology of ALL, especially in Canada. This retrospective cohort study used patient data from the Calgary Laboratory Services Cancer Cytogenetics Laboratory to report the incidence rate of ALL in Calgary, Alberta, Canada. New cases of ALL were identified for the 5-year period of January 1, 2011 until December 31, 2015. Reported incidence rates were categorized by sex and age groups, and age-standardized to the Canadian population.
There were an average of 11.4 new cases of ALL diagnosed per year between 2011 and 2015. The total incidence rate per 100,000 person-years was 0.84. Incidence rates peaked in children aged 0-4 with 7.55 and 3.32 cases per 100,000 person-years for males and females, respectively. The median age of diagnosis was 8 years. Incidence rates were generally lowest for adults aged 20 and over. The ratio of males to females diagnosed with ALL was 1.59. Overall, the recent incidence of ALL in Calgary is comparatively low with a preference for males and children below 5 years of age.
急性淋巴细胞白血病（ALL）是一种由异常淋巴干细胞发展而来的罕见恶性肿瘤。ALL的发病率在儿童中最高，到青春期逐渐下降。关于ALL流行病学的数据有限，尤其是在加拿大。这项回顾性队列研究使用了卡尔加里实验室服务癌症细胞遗传学实验室的患者数据，以报告加拿大艾伯塔省卡尔加里市ALL的发病率。确定了2011年1月1日至2015年12月31日这5年期间ALL的新病例。报告的发病率按性别和年龄组进行分类，并根据加拿大人口进行年龄标准化。
2011年至2015年期间，每年平均诊断出11.4例ALL新病例。每10万人年的总发病率为0.84。发病率在0至4岁儿童中达到峰值，男性和女性每10万人年的发病率分别为7.55例和3.32例。诊断的中位年龄为8岁。20岁及以上成年人的发病率通常最低。诊断为ALL的男性与女性比例为1.59。总体而言，卡尔加里市近期ALL的发病率相对较低，且男性和5岁以下儿童更为常见。
