Dizdarevic-Bostandzic Amela, Begovic Ermin, Burekovic Azra, Velija-Asimi Zelija, Godinjak Amina, Karlovic Vanja
Clinic for Nuclear Medicine and Endocrinology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Clinical Chemistry and Biochemistry, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Arch. 2018 Feb;72(1):13-16. doi: 10.5455/medarh.2018.72.13-16.
Diabetes mellitus(DM) is considered an independent cardiovascular risk factor. Having in mind concomitant occurence of diabetes and other cardiovascular risk factors, it is expected that patients with poor glucoregulation will have more cardiovascular risk factors and higher cardiovascular risk than patients with good glucoregulation.
To compare cardiovascular risk and cardiovascular risk factors between patients with poorly controlled and patients with well-controlled Diabetes mellitus.
Hundered ten patients aged 40-70 years suffering from Diabetes mellitus type 2 were included. Research is designed as a retrospective, descriptive study. Patients with glycosylated hemoglobin (HbA1c) > 7% were considered to have poorly controlled diabetes. The following data and parameters were monitored: age,sex, family history, data on smoking and alcohol consumption, BMI (body mass index), blood pressure, blood glucose, total cholesterol, triglycerides, LDL, HDL, fibrinogen, uric acid. For the assessment of cardiovascular risk, the WHO / ISH (World Health Organization/International Society of hypertension) tables of the 10-year risk were used, and due to the assessment of the risk factors prevalence, the optimal values of individual numerical variables were defined.
Differences in the mean values of systolic, diastolic blood pressure, fasting glucose, total cholesterol, LDL cholesterol are statistically significant higher in patients with poorly controlled diabetes. Hypertension more frequently occurre in patients with poorly controlled DM. The majority of patients with well-controlled DM belong to the group of low and medium cardiovascular risk, while the majority of patients with poorly controlled DM belong to the group of high and very high cardiovascular risk. In our research, there was a significant difference in cardiovascular risk in relation to the degree of DM regulation, and HbA1c proved to be an important indicator for the emergence of the CVD.
There are significant differences in certain risk factors between patients with poorly controlled and well controlled DM. Patients with poorly controlled diabetes mellitus have a higher cardiovascular risk than patients with well controlled diabetes. The value of HbA1c should be considered when assessing cardiovascular risk.
糖尿病（DM）被视为一种独立的心血管危险因素。鉴于糖尿病与其他心血管危险因素的同时存在，可以预期血糖调节不佳的患者比血糖调节良好的患者具有更多的心血管危险因素和更高的心血管风险。
比较糖尿病控制不佳患者与控制良好患者之间的心血管风险及心血管危险因素。
纳入110例年龄在40 - 70岁的2型糖尿病患者。本研究设计为回顾性描述性研究。糖化血红蛋白（HbA1c）> 7%的患者被认为糖尿病控制不佳。监测了以下数据和参数：年龄、性别、家族史、吸烟和饮酒数据、体重指数（BMI）、血压、血糖、总胆固醇、甘油三酯、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、纤维蛋白原、尿酸。为评估心血管风险，使用了世界卫生组织/国际高血压学会（WHO / ISH）的10年风险表，并且由于对危险因素患病率的评估，定义了各个数值变量的最佳值。
糖尿病控制不佳患者的收缩压、舒张压、空腹血糖、总胆固醇、低密度脂蛋白胆固醇的平均值差异在统计学上显著更高。高血压在糖尿病控制不佳的患者中更频繁出现。大多数糖尿病控制良好的患者属于低和中度心血管风险组，而大多数糖尿病控制不佳的患者属于高和极高心血管风险组。在我们的研究中，心血管风险与糖尿病调节程度存在显著差异，并且HbA1c被证明是心血管疾病发生的一个重要指标。
糖尿病控制不佳患者与控制良好患者在某些危险因素方面存在显著差异。糖尿病控制不佳的患者比糖尿病控制良好的患者具有更高的心血管风险。在评估心血管风险时应考虑HbA1c的值。
