Tong Ying, Yin Yong, Lu Jie, Liu Tonghai, Chen Jinhu, Cheng Pinjing, Gong Guanzhong
Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan.
School of Nuclear Science and Technology, University of South China, Hengyang, People's Republic of China.
Onco Targets Ther. 2018 Jan 24;11:547-554. doi: 10.2147/OTT.S155680. eCollection 2018.
The purpose of this study was to quantify variations in the heart, pericardium, and left ventricular myocardium (LVM) caused by cardiac movement using the breath-hold technique.
In this study, the electrocardiography-gated four-dimensional computed tomography (CT) images of 22 patients were analyzed, which were sorted into 20 phases (0-95%) according to the cardiac cycle. The heart, pericardium, and LVM were contoured on each phase of the CT images. The positions, volume, dice similarity coefficient (DSC) in reference to 0% phase, and morphological parameters (max 3D diameter, roundness, spherical disproportion, sphericity, and surface area) in different phases of the heart, pericardium, and LVM were analyzed, which were presented as mean ± standard deviation.
The mean values of displacements along the X, Y, and Z axes respectively were as follows: 1.2 mm, 0.6 mm, and 0.6 mm for the heart; 0.5 mm, 0.4 mm, and 0.8 mm for the pericardium; and 1.0 mm, 4.1 mm, and 1.9 mm for the LVM. The maximum variations in volume and DSC respectively were 16.49%±3.85% and 10.08%±2.14% for the heart, 12.62%±3.94% and 5.20%±1.54% for the pericardium, and 24.23%±11.35% and 184.33%±128.61% for the LVM. The differences in the morphological parameters between the maximum and minimum DSC phases for the heart and pericardium were not significantly different (>0.05) but were significantly different for the LVM (<0.05).
The volumetric and morphological variations of the heart were similar to those of pericardium, and all were significantly smaller than those of the LVM. This inconsistency in the volumetric and morphological variations between the LVM and the heart and pericardium indicates that special protection of the LVM should be considered.
本研究的目的是使用屏气技术量化心脏运动引起的心脏、心包和左心室心肌（LVM）的变化。
在本研究中，分析了22例患者的心电图门控四维计算机断层扫描（CT）图像，这些图像根据心动周期分为20个阶段（0 - 95%）。在CT图像的每个阶段对心脏、心包和LVM进行轮廓勾勒。分析了心脏、心包和LVM在不同阶段的位置、体积、相对于0%阶段的骰子相似系数（DSC）以及形态学参数（最大三维直径、圆度、球度差异、球形度和表面积），结果以平均值±标准差表示。
沿X、Y和Z轴的平均位移值分别如下：心脏为1.2毫米、0.6毫米和0.6毫米；心包为0.5毫米、0.4毫米和0.8毫米；LVM为1.0毫米、4.1毫米和1.9毫米。心脏体积和DSC的最大变化分别为16.49%±3.85%和10.08%±2.14%，心包为12.62%±3.94%和5.20%±1.54%，LVM为24.23%±11.35%和184.33%±128.61%。心脏和心包最大和最小DSC阶段之间的形态学参数差异无统计学意义（>0.05），但LVM有显著差异（<0.05）。
心脏的体积和形态变化与心包相似，且均明显小于LVM。LVM与心脏和心包在体积和形态变化上的这种不一致表明应考虑对LVM进行特殊保护。
