State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing, China.
Animal Husbandry and Veterinary Department, Beijing Vocational College of Agriculture, Beijing, China.
Front Immunol. 2018 Jan 24;9:5. doi: 10.3389/fimmu.2018.00005. eCollection 2018.
The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell location and this geographic proximity contributes to a large extent to their interaction. The onset and development of a great many diseases, such as inflammatory bowel disease and metabolic syndrome, will be caused due to the imbalance of body immune. As competent assistants, the intestinal bacteria are also critical in disease prevention and control. Moreover, the gut commensal bacteria are essential for development and normal operation of immune system and the pathogens are also closely bound up with physiological disorders and diseases mediated by immune imbalance. Understanding how our diet and nutrient affect bacterial composition and dynamic function, and the innate and adaptive status of our immune system, represents not only a research need but also an opportunity or challenge to improve health. Herein, this review focuses on the recent discoveries about intestinal bacteria-immune crosstalk and nutritional regulation on their interplay, with an aim to provide novel insights that can aid in understanding their interactions.
肠道是营养消化、微生物定植和免疫细胞定位的共同场所，这种地理上的邻近在很大程度上促进了它们的相互作用。许多疾病的发生和发展，如炎症性肠病和代谢综合征，将由于机体免疫的失衡而引起。作为有能力的助手，肠道细菌在疾病的预防和控制中也至关重要。此外，肠道共生细菌对于免疫系统的发育和正常运作是必需的，病原体也与免疫失衡介导的生理紊乱和疾病密切相关。了解我们的饮食和营养如何影响细菌组成和动态功能，以及我们的免疫系统的先天和适应性状态，不仅代表了一种研究需求，也是改善健康的机会或挑战。在此，本文综述了肠道细菌-免疫相互作用以及营养调节对其相互作用的最新发现，旨在提供有助于理解它们相互作用的新见解。
