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Immunohistological study of histiocytic necrotizing lymphadenitis.

作者信息

Kikuchi M, Takeshita M, Tashiro K, Mitsui T, Eimoto T, Okamura S

出版信息

Virchows Arch A Pathol Anat Histopathol. 1986;409(3):299-311. doi: 10.1007/BF00708248.

DOI:10.1007/BF00708248
PMID:2941916
Abstract

Immunohistological study of 18 cases of histiocytic necrotizing lymphadenitis (HNL) demonstrated numerous helper/inducer cells (OKT-4) and suppressor/cytotoxic cells (OKT-8) with activation (Tac) and proliferation (OKT-9) markers, and histiocytes (lysozyme, alpha-1 anti-chymotrypsin, OK-M1) in the affected areas. However, B cells (B-1), NK cells (Leu-7 and Leu-11), complement proteins and receptor (C4 and C3d receptor), and neutrophils (chloroacetate esterase) were scanty or absent in these foci. Activity of NK cells was also decreased in the peripheral blood of 2 cases examined. The results suggest that HNL might be induced by the abnormal T cell-histiocyte response against some causative agents which induce a similar reaction of delayed hypersensitivity type.

摘要

相似文献

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引用本文的文献

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Kikuchi-Fujimoto disease: A comprehensive review.菊池-藤本病：全面综述
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Necrotizing lymphadenitis (NEL) is a systemic disease characterized by blastic transformation of CD8+ cells and apoptosis of CD4+ cells.坏死性淋巴结炎（NEL）是一种全身性疾病，其特征为 CD8+细胞的母细胞转化和 CD4+细胞的凋亡。
Virchows Arch. 2014 Jan;464(1):95-103. doi: 10.1007/s00428-013-1516-z. Epub 2013 Nov 30.
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Kikuchi-Fujimoto disease: a case report.菊池-藤本病：一例病例报告。

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