Zhang Xinyu, Liu Liu, Yang Xi, Wang Lizhen, Zhang Chenping, Hu Yongjie
Department of Oral-maxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Medicine (Baltimore). 2018 Feb;97(6):e9795. doi: 10.1097/MD.0000000000009795.
In this study, we evaluated the effects of marsupialization in treating unicystic ameloblastoma (UA) and investigated the relationship between TP53 and interleukin 1 α (IL-1α) expression and the clinical outcome of UA treated with marsupialization.Consecutive patients treated with marsupialization and curettage at Shanghai Ninth People's Hospital were included. According to the unified standard, 48 patients were included in this study. Of these, 20 showed a good response, 10 a partial response, and 18 no response, based on the outcome of the marsupialization procedure. The expression of proteins TP53 and IL-1α was detected with immunohistochemistry (IHC). The clinical and pathological characteristics of the patients were analyzed.Analysis of the clinical and pathological characteristics showed that the effects of marsupialization treatment were significantly associated with lesion location (P < .001) and tumor diameter (P = .01). IHC showed that TP53 expression was significantly higher in the good-response group than in the partial- or no-response group (P = .02), and IL-1α expression was significantly higher in the good-response group than in the partial- and no-response groups (P = .03).Marsupialization is an effective preliminary procedure for treating UA before curettage and peripheral ostectomy. The expression of the TP53 and IL-1α proteins correlates directly with the outcome of UA treated with marsupialization.
在本研究中，我们评估了袋形术治疗单囊性成釉细胞瘤（UA）的效果，并研究了TP53和白细胞介素1α（IL-1α）表达与袋形术治疗UA临床结果之间的关系。纳入在上海第九人民医院接受袋形术和刮除术治疗的连续患者。根据统一标准，本研究纳入48例患者。其中，根据袋形术的结果，20例反应良好，10例部分反应，18例无反应。采用免疫组织化学（IHC）检测蛋白质TP53和IL-1α的表达。对患者的临床和病理特征进行分析。临床和病理特征分析表明，袋形术治疗效果与病变部位（P<0.001）和肿瘤直径（P=0.01）显著相关。免疫组织化学显示，反应良好组的TP53表达显著高于部分反应组或无反应组（P=0.02），反应良好组的IL-1α表达显著高于部分反应组和无反应组（P=0.03）。袋形术是刮除术和周边骨切除术之前治疗UA的有效初步程序。TP53和IL-1α蛋白的表达与袋形术治疗UA的结果直接相关。
