Wang Zhenxing, He Bowen, Xu Gefei, Wang Guojing, Wang Jiayi, Feng Yuhua, Su Dongmeng, Chen Bo, Li Hai, Wu Zhonghua, Zhang Hua, Shao Lu, Chen Hongyu
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing, 211816, China.
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Nat Commun. 2018 Feb 8;9(1):563. doi: 10.1038/s41467-018-02958-x.
Synthetic skills are the prerequisite and foundation for the modern chemical and pharmaceutical industry. The same is true for nanotechnology, whose development has been hindered by the sluggish advance of its synthetic toolbox, i.e., the emerging field of nanosynthesis. Unlike organic chemistry, where the variety of functional groups provides numerous handles for designing chemical selectivity, colloidal particles have only facets and ligands. Such handles are similar in reactivity to each other, limited in type, symmetrically positioned, and difficult to control. In this work, we demonstrate the use of polymer shells as adjustable masks for nanosynthesis, where the different modes of shell transformation allow unconventional designs beyond facet control. In contrast to ligands, which bind dynamically and individually, the polymer masks are firmly attached as sizeable patches but at the same time are easy to manipulate, allowing versatile and multi-step functionalization of colloidal particles at selective locations.
合成技术是现代化学和制药工业的前提和基础。纳米技术也是如此，其发展受到合成工具（即新兴的纳米合成领域）进展缓慢的阻碍。与有机化学不同，有机化学中官能团的多样性为设计化学选择性提供了众多途径，而胶体颗粒只有晶面和配体。这些途径在反应性上彼此相似，类型有限，对称分布，且难以控制。在这项工作中，我们展示了使用聚合物壳作为纳米合成的可调节掩膜，其中壳转变的不同模式允许超越晶面控制的非常规设计。与动态且单独结合的配体不同，聚合物掩膜以相当大的斑块形式牢固附着，但同时易于操作，从而能够在胶体颗粒的选择性位置进行多功能和多步官能化。
