Suppr超能文献

利用田菁合成 ZnO 纳米粒子及其抗糖尿病、抗晚期糖基化终产物和细胞毒性作用的评价。

Green Synthesising ZnO Nanoparticle Using Sesbania grandiflora and Their Evaluation of Anti-diabetic Anti-advanced Glycation End Products and Cytotoxic Effects.

机构信息

Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology-Vellore, Vellore, Tamil Nadu, 632 014, India.

出版信息

Appl Biochem Biotechnol. 2024 May;196(5):2652-2672. doi: 10.1007/s12010-023-04631-6. Epub 2023 Jul 11.

Abstract

Nanotechnology is an emerging area of science with diverse implementations, including medicine and drug delivery. Often for drug delivery, nanoparticles and nanocarriers were used. Diabetes mellitus is a metabolic disease with numerous complications, including advanced glycation end products (AGEs). AGEs advance neurodegeneration, obesity, renal dysfunction, retinopathy, and many more. Here, we have used zinc oxide nanoparticles synthesised with Sesbania grandiflora (hummingbird tree). ZnO nanoparticles and S. grandiflora are known for their biocompatibility and medicinal property, such as anti-cancer, anti-microbial, anti-diabetic, and anti-oxidant. So, we analysed the anti-diabetic, anti-oxidant, anti-AGEs, and cytotoxic effects of green synthesised and characterised ZnO nanoparticles with S. grandiflora (SGZ) and the leaf extract of S. grandiflora. Characterisation results indicated the synthesis of ZnO Nps at maximum concentration; the anti-oxidant assay showed 87.5% free radicle scavenging with DPPH. Additionally, anti-diabetic (72% α-amylase and 65% of α-glucosidase inhibition) and cell viability also exhibited promising results. In conclusion, SGZ can reduce the absorption of carbohydrates from the diet, elevate glucose uptake, and prevent protein glycation. So, it could be a potential tool for treating diabetes, hyperglycemia, and AGE-related diseases.

摘要

纳米技术是一个新兴的科学领域,具有多种应用,包括医学和药物输送。通常在药物输送中,使用纳米粒子和纳米载体。糖尿病是一种代谢疾病,有许多并发症,包括晚期糖基化终产物 (AGEs)。AGEs 会加速神经退行性变、肥胖、肾功能障碍、视网膜病变等。在这里,我们使用了用 Sesbania grandiflora(蜂鸟树)合成的氧化锌纳米粒子。氧化锌纳米粒子和 S. grandiflora 以其生物相容性和药用特性而闻名,如抗癌、抗菌、抗糖尿病和抗氧化。因此,我们分析了用 S. grandiflora(SGZ)和 S. grandiflora 叶提取物绿色合成和表征的 ZnO 纳米粒子的抗糖尿病、抗氧化、抗 AGEs 和细胞毒性作用。表征结果表明,在最大浓度下合成了 ZnO Nps;抗氧化测定显示 DPPH 自由基清除率为 87.5%。此外,还表现出了有希望的抗糖尿病(72%α-淀粉酶和 65%α-葡萄糖苷酶抑制)和细胞活力作用。总之,SGZ 可以减少饮食中碳水化合物的吸收,提高葡萄糖摄取,并防止蛋白质糖化。因此,它可能是治疗糖尿病、高血糖和与 AGE 相关疾病的潜在工具。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验