杜克雷嗜血杆菌在体外对壮观霉素的敏感性。
Susceptibility of Haemophilus ducreyi to spectinomycin in vitro.
作者信息
Hafiz S, Jones B M, Kinghorn G R, Duerden B I
出版信息
Genitourin Med. 1986 Aug;62(4):251-2. doi: 10.1136/sti.62.4.251.
Abstract
Using an agar dilution technique with standardised inocula prepared by ultrasonication, the minimum inhibitory concentrations (MICs) of spectinomycin were determined for 66 strains of Haemophilus ducreyi, eight of which were beta lactamase producers. All strains were sensitive to concentrations of spectinomycin, which were well within the therapeutic ranges attained with normal dosage. The MIC50 and MIC90 were 8 mg/l, (range 0.007-16 mg/l).
摘要
采用琼脂稀释法，使用经超声处理制备的标准化接种物，测定了66株杜克雷嗜血杆菌对壮观霉素的最低抑菌浓度（MIC），其中8株为β-内酰胺酶产生菌。所有菌株对壮观霉素的浓度均敏感，这些浓度完全在正常剂量所能达到的治疗范围内。MIC50和MIC90分别为8mg/l（范围为0.007 - 16mg/l）。
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