壮观霉素类似物U-63366、新型大环内酯类抗生素罗红霉素（RU 28965）以及五种喹诺酮衍生物对杜克雷嗜血杆菌的体外活性。
In vitro activities of U-63366, a spectinomycin analog; roxithromycin (RU 28965), a new macrolide antibiotic; and five quinolone derivatives against Haemophilus ducreyi.
作者信息
Sanson-Le Pors M J, Casin I M, Thebault M C, Arlet G, Perol Y
出版信息
Antimicrob Agents Chemother. 1986 Sep;30(3):512-3. doi: 10.1128/AAC.30.3.512.
Abstract
The in vitro activities of the new spectinomycin analog U-63366, the new macrolide roxithromycin (RU 28965), and five new quinolone derivatives (pefloxacin, rosoxacin, norfloxacin, ofloxacin, and ciprofloxacin) were studied against 23 multiresistant strains of Haemophilus ducreyi (beta-lactamase producers) isolated in Paris and were compared with the activities of tetracycline, minocycline, chloramphenicol, streptomycin, kanamycin, gentamicin, spectinomycin, erythromycin, and nalidixic acid. All strains were uniformly susceptible to the seven new antibiotics tested. Ciprofloxacin had the greatest inhibitory effect in vitro (the MIC for 90% of the strains tested [MIC90] was 0.016 microgram/ml), and U-63366 was the most active aminoglycoside-aminocyclitol antibiotic (MIC90, 0.25 microgram/ml).
摘要
研究了新型壮观霉素类似物U - 63366、新型大环内酯类药物罗红霉素（RU 28965）以及五种新型喹诺酮衍生物（培氟沙星、咯索沙星、诺氟沙星、氧氟沙星和环丙沙星）对在巴黎分离出的23株多重耐药性杜克雷嗜血杆菌（产生β - 内酰胺酶）的体外活性，并与四环素、米诺环素、氯霉素、链霉素、卡那霉素、庆大霉素、壮观霉素、红霉素和萘啶酸的活性进行了比较。所有菌株对所测试的七种新型抗生素均表现出一致的敏感性。环丙沙星在体外具有最大的抑制作用（所测试菌株中90%的最低抑菌浓度[MIC90]为0.016微克/毫升），而U - 63366是活性最高的氨基糖苷 - 氨基环醇类抗生素（MIC90为0.25微克/毫升）。
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