β-氨基异丁酸，l-BAIBA，是一种肌肉来源的破骨细胞存活因子。
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor.
机构信息
Department of Anatomy and Cell Biology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA; Department of Oral & Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
出版信息
Cell Rep. 2018 Feb 6;22(6):1531-1544. doi: 10.1016/j.celrep.2018.01.041.
Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.
运动对新陈代谢和组织有有益影响。运动诱导的肌肉因子β-氨基异丁酸（BAIBA）在白色脂肪的褐色化和胰岛素抵抗中起着关键作用。在这里，我们展示了 BAIBA 的另一个功能，即作为一种骨保护因子，可防止活性氧（ROS）诱导的破骨细胞死亡。l-BAIBA 与雌激素或 N-乙酰半胱氨酸一样具有保护作用，或更具保护作用，通过 Mas 相关 G 蛋白偶联受体类型 D（MRGPRD）信号传导，防止由于 ROS 导致的线粒体破裂。在鼠后肢去负荷模型（破骨细胞凋亡模型）中，饮用水中补充 BAIBA 可防止骨丢失和肌肉功能丧失。BAIBA 的保护作用随年龄的增长而丧失，这不是由于肌肉产生 BAIBA 的能力丧失，而是可能随着年龄的增长，Mrgprd 的表达减少。这对于理解衰老过程中运动对骨骼的作用减弱具有重要意义。
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