Cancer Sciences, University of Southampton, UK; University Surgical Unit, University of Southampton, UK.
Cancer Sciences, University of Southampton, UK.
Cancer Lett. 2018 Apr 28;420:228-235. doi: 10.1016/j.canlet.2018.02.002. Epub 2018 Feb 7.
Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.
外泌体是可以在细胞间传递分子货物的分泌囊泡。近年来，外泌体 microRNAs（exomiRs）引起了广泛关注，因为越来越多的证据表明，microRNAs 加载到外泌体中不是一个随机的过程。临床前研究已经确定了 exomiRs 在影响癌症许多特征方面的功能作用。支持其作用的机制，如 exomiR 受体（“miRceptors”），现在已经变得明显。更令人兴奋的是，事实上，exomiRs 是作为个性化癌症医学时代的非侵入性生物标志物的非常合适的候选者。
