Reproductive Medicine Center, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan, 410008, People's Republic of China.
Reprod Biol Endocrinol. 2018 Feb 9;16(1):13. doi: 10.1186/s12958-018-0324-3.
There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to establish whether vitamin D was associated with clinical outcomes of IVF/ICSI.
MEDLINE, Google Scholar and the Cochrane Library from database inception to March 2017 were searched. Clinical studies, which evaluated the association of vitamin D level and the clinical outcomes after IVF/ICSI, were included. The Main Outcome Measures were clinical pregnancy, ongoing pregnancy, and live birth.
In the analysis of clinical pregnancy, 9 cohort studies were included. Of which, 2 studies and 3 studies were identified in analyzing ongoing pregnancy and live birth, respectively. Meta-analysis showed trends toward lower clinical pregnancy [RR 0.91, (95% CI 0.77-1.07)] and higher ongoing pregnancy [RR 1.06, (95% CI 0.95-1.19)] for women with deficient level of vitamin D. The probability of live birth for women with deficient level of vitamin D was significantly lower than cases with sufficient level of vitamin D [RR 0.74, (95% CI 0.58-0.90)].
Deficient vitamin D was associated with decreased probability of live birth after IVF/ICSI. So vitamin D should be supplied to women with deficient level vitamin D.
维生素 D 与体外受精（IVF）和/或卵胞浆内单精子注射（ICSI）的临床结局是否有关存在矛盾的观点。本荟萃分析旨在确定维生素 D 是否与 IVF/ICSI 的临床结局有关。
从数据库建立到 2017 年 3 月，检索 MEDLINE、Google Scholar 和 Cochrane 图书馆。纳入评估维生素 D 水平与 IVF/ICSI 后临床结局相关性的临床研究。主要结局指标是临床妊娠、持续妊娠和活产。
在分析临床妊娠时，纳入了 9 项队列研究。其中，有 2 项研究和 3 项研究分别用于分析持续妊娠和活产。荟萃分析显示，维生素 D 水平不足的女性临床妊娠[RR 0.91，（95% CI 0.77-1.07）]和持续妊娠[RR 1.06，（95% CI 0.95-1.19）]的几率较低。维生素 D 水平不足的女性活产的可能性明显低于维生素 D 水平充足的女性[RR 0.74，（95% CI 0.58-0.90）]。
维生素 D 不足与 IVF/ICSI 后活产几率降低有关。因此，应向维生素 D 水平不足的女性提供维生素 D。
