Noda H
Nihon Geka Gakkai Zasshi. 1986 Jun;87(6):636-41.
It has been shown in the previous reports the immune system of mice is activated during liver regeneration following partial hepatectomy and lymph node cells activated in vivo suppress the syngeneic mixed hepatectomized liver cell-lymphocyte reaction (sMLHLR). In this report, it is demonstrated that the suppressor activity of lymphocytes in vivo by liver regeneration exists in lymph node T cells and splenic adherent cells, but not in lymph node B cells. This suppressive activity of splenic adherent cells is blocked with indomethacin or aspirin. Each of these compounds in nontoxic doses inhibited macrophage-mediated suppression suggesting that the release of prostaglandins by macrophages played an essential role in inhibiting the sMLHLR.
先前的报告显示，在部分肝切除术后的肝脏再生过程中，小鼠的免疫系统被激活，体内激活的淋巴结细胞会抑制同基因混合肝切除肝细胞-淋巴细胞反应（sMLHLR）。在本报告中，证明了肝脏再生在体内诱导的淋巴细胞抑制活性存在于淋巴结T细胞和脾脏黏附细胞中，而不存在于淋巴结B细胞中。脾脏黏附细胞的这种抑制活性可被吲哚美辛或阿司匹林阻断。这些化合物在无毒剂量下均可抑制巨噬细胞介导的抑制作用，提示巨噬细胞释放前列腺素在抑制sMLHLR中起重要作用。
