Institute of Public Health and Medical Service, Seoul National University Hospital, Seoul, Republic of Korea; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Environ Int. 2018 Apr;113:177-183. doi: 10.1016/j.envint.2018.02.004. Epub 2018 Feb 8.
Lung function is a major predictor of morbidity and mortality. Only a few studies have explored the association between phthalate exposure and lung function.
To evaluate the association between phthalate exposure and lung function in the elderly.
A total of 3 repeated-measures surveys were conducted in 559 elderly individuals aged ≥60 years in Seoul, Korea, at 1-year intervals (2012-2015). During each survey, urinary mono-(2-ethyl-5-hydrohexyl) phthalate (MEHHP) (geometric mean, 15.68 μg/L), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (11.97 μg/L), and mono-n-butyl phthalate (MnBP) (2.09 μg/L) levels were measured; moreover, lung function tests and a structured questionnaire interview were performed. We constructed linear mixed models to assess the association between urinary phthalate metabolite levels and lung function.
A doubling of creatinine-adjusted urinary phthalate metabolite levels was inversely associated with forced expiratory volume in 1 s (L) (β = -0.01, 95% confidence interval [CI]: -0.02, 0.004 for MEHHP; β = -0.02, 95% CI: -0.03, -0.01 for MEOHP; β = -0.01, 95% CI: -0.03, -0.003 for MnBP) and forced vital capacity (L) (β = -0.02, 95% CI: -0.03, -0.001 for MEHHP; β = -0.02, 95% CI: -0.03, -0.004 for MEOHP; β = -0.02, 95% CI: -0.03, -0.001 for MnBP). A doubling of creatinine-adjusted MnBP levels was associated with increased rates of annual decline in forced vital capacity (L/year) (β = -0.01, 95% CI: -0.02, -0.001).
Urinary phthalate metabolite levels were associated with lower lung function and an increased rate of decline in lung function in an elderly population.
肺功能是发病率和死亡率的主要预测因素。只有少数研究探讨了邻苯二甲酸酯暴露与肺功能之间的关系。
评估老年人邻苯二甲酸酯暴露与肺功能之间的关系。
在韩国首尔，对 559 名年龄≥60 岁的老年人进行了 3 次重复测量调查，间隔 1 年（2012-2015 年）。在每次调查中，测量了尿中单-(2-乙基-5-己基)邻苯二甲酸酯（MEHHP）（几何平均值，15.68μg/L）、单-(2-乙基-5-氧代己基)邻苯二甲酸酯（MEOHP）（11.97μg/L）和单正丁基邻苯二甲酸酯（MnBP）（2.09μg/L）水平；此外，还进行了肺功能检查和结构化问卷调查。我们构建了线性混合模型来评估尿中邻苯二甲酸代谢物水平与肺功能之间的关系。
肌酐调整后的尿邻苯二甲酸代谢物水平加倍与 1 秒用力呼气量（L）（β= -0.01，95%置信区间[CI]：-0.02，0.004 对于 MEHHP；β= -0.02，95% CI：-0.03，-0.01 对于 MEOHP；β= -0.01，95% CI：-0.03，-0.003 对于 MnBP）和用力肺活量（L）（β= -0.02，95% CI：-0.03，-0.001 对于 MEHHP；β= -0.02，95% CI：-0.03，-0.004 对于 MEOHP；β= -0.02，95% CI：-0.03，-0.001 对于 MnBP）呈负相关。肌酐调整后的 MnBP 水平加倍与用力肺活量年下降率（L/年）增加有关（β= -0.01，95% CI：-0.02，-0.001）。
尿邻苯二甲酸酯代谢物水平与老年人较低的肺功能和肺功能下降率增加有关。
