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预测酒精、烟草、大麻或阿片成瘾患者的渴望和物质使用:跨物质的共性和特异性。

Predictors of craving and substance use among patients with alcohol, tobacco, cannabis or opiate addictions: Commonalities and specificities across substances.

机构信息

Univ. Bordeaux, Bordeaux, France; Equipe addiction (laboratoire de psychiatrie), SANPSY, CNRS USR 3413, Bordeaux, France; Département d'Addictologie, CH Charles Perrens and CHU de Bordeaux, Bordeaux, France.

Univ. Bordeaux, Bordeaux, France; Equipe addiction (laboratoire de psychiatrie), SANPSY, CNRS USR 3413, Bordeaux, France; Center for Studies of Addiction, Department of psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Addict Behav. 2018 Aug;83:123-129. doi: 10.1016/j.addbeh.2018.01.041. Epub 2018 Feb 2.

Abstract

INTRODUCTION

Craving has been proposed as a major contributor to addiction relapse and the influence of mood on craving and substance use has been extensively documented. However, information is lacking concerning the extent to which the magnitude of these effects may vary according to different types of substances. The aim of the present study was to compare the prospective links between emotions, craving and substance use in four groups of patients beginning treatment for alcohol, tobacco, cannabis, or opiate addiction.

METHODS

Ecological Momentary Assessment (EMA) was used over a two-week period. Data were analyzed using hierarchical linear modeling (HLM).

RESULTS

159 participants were recruited (67.3% male; M = 36.7 years). The average response rate to the EMA assessments was 83.1%. The findings confirmed the strong predictive role of craving intensity on substance use reported at the next assessment of the day among the alcohol (γ = 0.224; p = .018), tobacco (γ = 0.133; p = .013) and cannabis groups (γ = 0.266; p = .019), but not for opiates (γ = 0.098; p = .142). Craving intensity was itself predicted by greater anxious mood (γ = 0.108; p = 0,029) and event negativity (γ = 0.107; p = .003) among tobacco patients, lower sad mood among cannabis patients (γ = -0.248; p = 0,002), and lower event negativity among opiate patients (γ = -0.201; p = .002).

CONCLUSION

While these results support the benefit of targeting craving in addiction treatment regardless of substance type, the substance-specific emotional risk factors for craving identified in this study may provide important insights for the development of personalized treatment strategies.

摘要

简介

成瘾复发的主要原因之一是成瘾者的欲望,而情绪对欲望和物质使用的影响已得到广泛证实。然而,关于这些影响的程度可能因不同类型的物质而有所不同的信息却很缺乏。本研究的目的是比较在开始接受酒精、烟草、大麻或阿片类药物成瘾治疗的四组患者中,情绪、欲望和物质使用之间的前瞻性联系。

方法

使用生态瞬时评估(EMA)在两周的时间内进行评估。使用分层线性建模(HLM)对数据进行分析。

结果

共招募了 159 名参与者(67.3%为男性;M=36.7 岁)。对 EMA 评估的平均应答率为 83.1%。研究结果证实,在接下来的一天的评估中,欲望强度对酒精(γ=0.224;p=0.018)、烟草(γ=0.133;p=0.013)和大麻(γ=0.266;p=0.019)组的物质使用具有很强的预测作用,但对阿片类药物(γ=0.098;p=0.142)没有预测作用。在烟草患者中,欲望强度本身受到更强烈的焦虑情绪(γ=0.108;p=0.029)和事件负性(γ=0.107;p=0.003)的预测,在大麻患者中受到更强烈的悲伤情绪(γ=-0.248;p=0.002)的预测,而在阿片类药物患者中受到事件负性(γ=-0.201;p=0.002)的预测。

结论

虽然这些结果支持无论物质类型如何,在成瘾治疗中靶向欲望的益处,但本研究确定的针对欲望的特定物质的情绪风险因素可能为制定个性化治疗策略提供重要的见解。

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