Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway.
作者信息
Pekmezci Melike, Stevers Meredith, Phillips Joanna J, Van Ziffle Jessica, Bastian Boris C, Tsankova Nadejda M, Kleinschmidt-DeMasters Bette K, Rosenblum Marc K, Tihan Tarik, Perry Arie, Solomon David A
机构信息
Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Department of Neurological Surgery, University of California, San Francisco, CA, USA.
出版信息
Acta Neuropathol. 2018 Mar;135(3):485-488. doi: 10.1007/s00401-018-1820-4. Epub 2018 Feb 10.
Abstract
摘要
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Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway.大脑多结节性空泡状神经元肿瘤是一种克隆性肿瘤，由激活丝裂原活化蛋白激酶信号通路的基因改变所定义。
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Mod Pathol. 2018 Apr;31(4):581-597. doi: 10.1038/modpathol.2017.160. Epub 2017 Dec 1.
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Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?癫痫性多结节和空泡性神经元肿瘤：发育不良还是肿瘤？
Brain Pathol. 2018 Mar;28(2):155-171. doi: 10.1111/bpa.12555. Epub 2017 Sep 19.
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Natural history of lesions with the MR imaging appearance of multinodular and vacuolating neuronal tumor.具有多结节和空泡状神经元肿瘤磁共振成像表现的病变的自然史
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Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New "Leave Me Alone" Lesion with a Characteristic Imaging Pattern.大脑多结节性和空泡性神经元肿瘤：一种具有特征性影像学模式的新的“别理我”病变。
AJNR Am J Neuroradiol. 2017 Oct;38(10):1899-1904. doi: 10.3174/ajnr.A5281. Epub 2017 Jul 13.
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Multinodular and Vacuolating Neuronal Tumor: A Rare Seizure-associated Entity.多结节性空泡状神经元肿瘤：一种罕见的与癫痫发作相关的病变。
Am J Surg Pathol. 2017 Jul;41(7):1005-1010. doi: 10.1097/PAS.0000000000000868.
6
Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.对儿科神经肿瘤患者进行靶向二代测序可改善诊断、识别致病性种系突变并指导靶向治疗。
Neuro Oncol. 2017 May 1;19(5):699-709. doi: 10.1093/neuonc/now254.
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Acta Neuropathol. 2017 Mar;133(3):417-429. doi: 10.1007/s00401-016-1639-9. Epub 2016 Nov 3.
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Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis.朗格汉斯细胞组织细胞增生症中BRAF激活的替代遗传机制。
Blood. 2016 Nov 24;128(21):2533-2537. doi: 10.1182/blood-2016-08-733790. Epub 2016 Oct 11.
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Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.MAP2K1和BRAF中相互排斥的复发性体细胞突变支持ERK激活在朗格汉斯细胞组织细胞增生症（LCH）发病机制中起核心作用。
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